* Zobrazit nápovědu

149 záznamů v PubMed Filtry

Článek

Citalopram u depresí (Výsledky otevrené multicentrické studie v rámci IV. etapy klinického hodnocení)
[Citalopram in depression (results of an open multicenter study in phase IV of the clinical trial)]

Ceskoslovenska psychiatrie. 1993 Dec ; 89 (6) : 340-8.

Cesk Psychiatr
ISSN 0069-2336
Zdroj

249 depressed patients were treated by 35 psychiatrists in an open multicenter trial during 6 weeks with citalopram. The protocol enabled that naturalistic treatment conditions could be kept. The results were rated with the help of the Clinical Global Impression (CGI) scale. The treatment was successful in 77% of the patients. 5 patients dropped out because of adverse effects, 8 patients did not finish the trial due to insufficient efficacy. In 160 patients (64.2%) no adverse effects were registered. Transient mild headaches in 8.4% and nausea in 4% were the most frequent adverse events. The best effects were observed in patients who were rated as moderately ill (82.8% ameliorated) at pretreatment. Nevertheless, also 66.7% of those rated as severely ill before the treatment improved substantially. In patients treated with higher doses than 20 mg/day, the improvement rate was not higher than in those treated with 20 mg daily.

MeSH
citalopram škodlivé účinky terapeutické užití MeSH
depresivní poruchy farmakoterapie MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
senioři MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
klinické zkoušky, fáze IV MeSH
klinické zkoušky MeSH
multicentrická studie MeSH
Názvy látek
citalopram MeSH

Článek

Neuroscience in Czechoslovakia

Trends in neurosciences. 1991 Jan ; 14 (1) : 11-3.

Trends Neurosci
ISSN 0166-2236
Zdroj

The collapse of the communist regime in Czechoslovakia revealed not only the disastrous state of the Czechoslovak economy but also the serious problems that Czechoslovak science faces. Understanding the present situation and determining the best way to improve it requires careful analysis of the development of science during the past 40 years.

MeSH
lidé MeSH
neurologie trendy MeSH
zvířata MeSH
Check Tag
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
Geografické názvy
Československo MeSH

Článek

Effects of drug administration in pregnancy on children's school behaviour

Pharmaceutisch weekblad. Scientific edition. 1990 Dec 14 ; 12 (6) : 252-5.

Pharm Weekbl Sci
ISSN 0167-6555
Zdroj

Files with prescription data were used to assess possible behavioural changes in children, whose mothers used benzodiazepines or neuroleptic drugs during the second half of their pregnancy. Prescriptions, bearing the identification number of women resident in one district of Prague, filed in pharmacies during 1974 and the first three months of 1975 represent the first part of the data. During 1984, children born in the appropriate earlier period were searched and linked with the earlier prescription data. A group of 68 children with possible exposure to neuroleptics and a group of 15 children possibly exposed to diazepam during the second half of their intrauterine development were found. Two groups of 55 and 7 children, respectively, born of mothers without exposure to these drugs, were chosen as controls. The teachers of classes attended by these children were addressed by a letter and asked to evaluate their behaviour at school. This was done by means of a form containing analogue scales evaluating different features of behaviour. Each child was compared with its control. The statistical evaluation with Student's t-test, regression analysis and analysis of variance did not reveal any significant difference between both groups and their controls.