Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic; therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.

• Klíčová slova
• Biomineralization, Ferritin, Human tissues, Iron oxides,
• MeSH
• ferritiny metabolismus   MeSH
• lidé MeSH
• mozek metabolismus   MeSH
• neurodegenerativní nemoci metabolismus   patologie   MeSH
• oxidy metabolismus   MeSH
• železo metabolismus   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• ferritiny MeSH
• oxidy MeSH
• železo MeSH

Iron is very important element for functioning of the brain. Its concentration changes with aging the brain or during disease. The aim of our work was the histological examination of content of ferritin and free iron (unbound) in brain cortex in association with Abeta plaques from their earliest stages of accumulation in amyloid plaque forming APP/PS1 transgenic mice. Light microscopy revealed the onset of plaques formation at 8-monthage. Detectable traces of free iron and no ferritin were found around plaques at this age, while the rate of their accumulation in and around Abeta plaques was elevated at 13 months of age. Ferritin accumulated mainly on the edge of Abeta plaques, while the smaller amount of free iron was observed in the plaque-free tissue, as well as in and around Abeta plaques. We conclude that free iron and ferritin accumulation follows the amyloid plaques formation. Quantification of cortical iron and ferritin content can be an important marker in the diagnosis of Alzheimer's disease.

• MeSH
• Alzheimerova nemoc metabolismus   MeSH
• amyloidní plaky metabolismus   MeSH
• ferritiny metabolismus   MeSH
• modely nemocí na zvířatech MeSH
• mozková kůra metabolismus   MeSH
• myši transgenní MeSH
• železo metabolismus   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• ferritiny MeSH
• železo MeSH

UNLABELLED: PURPOSE OF THE STUDY With the concept of the lateral compression plate (LLCP) a technique has been available designed to combine the advantages of a fixed-angle fixation with a complete sinking of the implant into the proximal bone. The objective of the present study was to investigate the results of the LLCP compared with classical screw osteosynthesis (SO). MATERIAL AND METHODS 31 patients with pes planovalgus who received calcaneal displacement osteotomy and osteosyntheses with screws (n = 17) or LLCP (n = 14) between 2010 and 2015 were investigated retrospectively.The ankle-hindfoot scale, Kaikkonen score, VAS, and the SF-36 were determined preoperatively as well as at the last clinical follow-up. In addition, a radiological control of osseous integration was performed in all patients 12 weeks after surgery. RESULTS With regard to clinical scores both methods depicted significant improvement. In the overall cohort there were no pseudarthroses. In the SO group 5 cases (29%) showed hardware irritation, in the LLCP group there were none. Results in the LLCP group were significantly superior in the area of the physical section of the SF 36. CONCLUSIONS Based on the results of our study, surgical treatment of stage II pes planovalgus by means of calcaneal displacement osteotomy using the LLCP is equivalent to SO with a lower incidence of hardware irritation. Key words:pes planovalgus, lateral compression plate, osteosynthesis, screw, hardware irritation. LEVEL OF EVIDENCE: Level IV, retrospective case serie.

• MeSH
• hodnocení výsledků zdravotní péče MeSH
• kostní destičky MeSH
• kostní šrouby MeSH
• kostní svalek diagnostické zobrazování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• osteotomie * škodlivé účinky   přístrojové vybavení   metody   MeSH
• patní kost chirurgie   MeSH
• plochá noha diagnóza   chirurgie   MeSH
• pooperační komplikace * diagnóza   etiologie   prevence a kontrola   MeSH
• poranění měkkých tkání * diagnóza   etiologie   prevence a kontrola   MeSH
• srovnávací výzkum účinnosti MeSH
• vnitřní fixace fraktury * škodlivé účinky   přístrojové vybavení   metody   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Německo MeSH