This study investigates the factors contributing to bicycle accidents, focusing on four types of bicycle lanes and other exposure and built environment characteristics of census blocks. Using Seoul as a case study, three years of bicycle accident spot data from 2018 to 2020 was collected, resulting in 1,330 bicycle accident spots and a total of 2,072 accidents. The geographically weighted Poisson regression (GWPR) model was used as a methodological approach to investigate the spatially varying relationships between the accident frequency and explanatory variables across the space, as opposed to the Poisson regression model. The results indicated that the GWPR model outperforms the global Poisson regression model in capturing unobserved spatial heterogeneity. For example, the value of deviance that determines the goodness of fit for a model was 0.244 for the Poisson regression model and 0.500 for the far better-fitting GWPR model. Further findings revealed that the factors affecting bicycle accidents have varying impacts depending on the location and distribution of accidents. For example, despite the presence of bicycle lanes, some census blocks, particularly in the northeast part of the city, still pose a risk for bicycle accidents. These findings can provide valuable insights for urban planners and policymakers in developing bicycle safety measures and regulations.

• Klíčová slova
• Bicycle accident, Bicycle lane types, Geographically weighted regression, Seoul,
• MeSH
• bezpečnost statistika a číselné údaje   MeSH
• cyklistika * zranění   statistika a číselné údaje   MeSH
• dopravní nehody * statistika a číselné údaje   MeSH
• lidé MeSH
• Poissonovo rozdělení MeSH
• prostorová regrese MeSH
• rizikové faktory MeSH
• vytvořené prostředí statistika a číselné údaje   MeSH
• životní prostředí - projekt * statistika a číselné údaje   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Soul epidemiologie   MeSH

OBJECTIVE: Bladder exstrophy (BE) is a rare but severe birth defect affecting the lower abdominal wall and genitourinary system. The objective of the study is to examine the total prevalence, trends in prevalence, and age-specific mortality among individuals with BE. STUDY DESIGN: We conducted a retrospective cohort study. Data were analyzed from 20 birth defects surveillance programs, members of the International Clearinghouse for Birth Defects Surveillance and Research in 16 countries. Live births, stillbirths, and elective terminations of pregnancy for fetal anomaly (ETOPFA) diagnosed with BE from 1974 to 2014. Pooled and program-specific prevalence of BE per 100,000 total births was calculated. The 95% confidence intervals (CI) for prevalence were estimated using Poisson approximation of binomial distribution. Time trends in prevalence of BE from 2000 to 2014 were examined using Poisson regression. Proportion of deaths among BE cases was calculated on the day of birth, day 2 to 6, day 7 to 27, day 28 to 364, 1 to 4 years, and ≥5 years. Mortality analysis was stratified by isolated, multiple, and syndromic case status. RESULTS: The pooled total prevalence of BE was 2.58 per 100,000 total births (95% CI = 2.40, 2.78) for study years 1974 to 2014. Prevalence varied over time with a decreasing trend from 2000 to 2014. The first-week mortality proportion was 3.5, 17.3, and 14.6% among isolated, multiple, and syndromic BE cases, respectively. The majority of first-week mortality occurred on the first day of life among isolated, multiple, and syndromic BE cases. The proportion of first-week deaths was higher among cases reported from programs in Latin America where ETOPFA services were not available. CONCLUSION: Prevalence of BE varied by program and showed a decreasing trend from 2000 to -2014. Mortality is a concern among multiple and syndromic cases, and a high proportion of deaths among cases occurred during the first week of life. KEY POINTS: · Total prevalence of BE was 2.58 per 100,000 births.. · Prevalence decreased from 2000 to 2014.. · The first-week mortality was 9.3%..

• MeSH
• dítě MeSH
• ekstrofie močového měchýře * epidemiologie   MeSH
• kojenec MeSH
• lidé MeSH
• novorozenec MeSH
• Poissonovo rozdělení MeSH
• předškolní dítě MeSH
• prevalence MeSH
• retrospektivní studie MeSH
• těhotenství MeSH
• Check Tag
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• mužské pohlaví MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: This study aims to estimate the association between radon and site-specific cancer mortality among a large contemporary cohort of male uranium miners. METHODS: Annual occupational radon exposure was estimated based on a worker's duration of underground mining in a year and estimates of potential alpha energy of radon progeny in their location of work. Cancer mortality over the period 1977-1992 was ascertained for a cohort of 16 434 male underground uranium miners employed in the Czech Republic between 1946 and 1992. Poisson regression was used to estimate relationships between cumulative radiation exposure (in working level months [WLM]) and site-specific cancer mortality. RESULTS: Radon is positively associated with lung cancer mortality (excess relative rate [ERR] per 100 WLM = 0.2; 95% confidence interval [CI]: 0.10, 0.37). The best fit of the dose-response relationship between radon and lung cancer mortality was linear and estimates of radon-lung cancer associations varied by windows of time-since-exposure. Positive associations between radon and several types of cancer other than lung cancer were identified, notably chronic lymphocytic leukemia (CLL) (ERR/100 WLM = 0.24; 95% CI: [not determined [ND], 5.10]) and extrathoracic cancer (ERR/100 WLM = 0.12; 95% CI: [ND, 0.69]). We observed no associations between radon and stomach cancer, nor between radon and several hematopoietic cancer subtypes. CONCLUSIONS: This study confirms the established radon-lung cancer association and suggests that radon may also be associated with other types of cancer mortality. Further investigations of extrathoracic and CLL cancer, with the aim of obtaining more precise estimates, are warranted to understand associations between radon and cancers other than lung.

• Klíčová slova
• cancer, lung cancer, radon, uranium mining,
• MeSH
• chronická lymfatická leukemie etiologie   mortalita   MeSH
• hornictví * MeSH
• lidé MeSH
• nádory plic etiologie   mortalita   MeSH
• nádory vyvolané zářením mortalita   MeSH
• nemoci z povolání etiologie   mortalita   MeSH
• Poissonovo rozdělení MeSH
• pracovní expozice škodlivé účinky   MeSH
• radon toxicita   MeSH
• uran * MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Research Support, N.I.H., Extramural MeSH
• Research Support, N.I.H., Intramural MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• radon MeSH
• uran * MeSH

The rate coding hypothesis is the oldest and still one of the most accepted and investigated scenarios in neuronal activity analyses. However, the actual neuronal firing rate, while informally understood, can be mathematically defined in several different ways. These definitions yield distinct results; even their average values may differ dramatically for the simplest neuronal models. Such an inconsistency, together with the importance of "firing rate," motivates us to revisit the classical concept of the instantaneous firing rate. We confirm that different notions of firing rate can in fact be compatible, at least in terms of their averages, by carefully discerning the time instant at which the neuronal activity is observed. Two general cases are distinguished: either the inspection time is synchronised with a reference time or with the neuronal spiking. The statistical properties of the instantaneous firing rate, including parameter estimation, are analyzed, and compatibility with the intuitively understood concept is demonstrated.

• MeSH
• akční potenciály * MeSH
• axony fyziologie   MeSH
• lidé MeSH
• modely neurologické MeSH
• nervová síť * MeSH
• nervový přenos MeSH
• neurony fyziologie   MeSH
• normální rozdělení MeSH
• počítačová simulace MeSH
• Poissonovo rozdělení MeSH
• pravděpodobnost MeSH
• statistické modely MeSH
• stochastické procesy MeSH
• synapse MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Photonic signals are broadly exploited in communication and sensing and they typically exhibit Poisson-like statistics. In a common scenario where the intensity of the photonic signals is low and one needs to remove a nonstationary trend of the signals for any further analysis, one faces an obstacle: due to the dependence between the mean and variance typical for a Poisson-like process, information about the trend remains in the variance even after the trend has been subtracted, possibly yielding artifactual results in further analyses. Commonly available detrending or normalizing methods cannot cope with this issue. To alleviate this issue we developed a suitable pre-processing method for the signals that originate from a Poisson-like process. In this paper, a Poisson pre-processing method for nonstationary time series with Poisson distribution is developed and tested on computer-generated model data and experimental data of chemiluminescence from human neutrophils and mung seeds. The presented method transforms a nonstationary Poisson signal into a stationary signal with a Poisson distribution while preserving the type of photocount distribution and phase-space structure of the signal. The importance of the suggested pre-processing method is shown in Fano factor and Hurst exponent analysis of both computer-generated model signals and experimental photonic signals. It is demonstrated that our pre-processing method is superior to standard detrending-based methods whenever further signal analysis is sensitive to variance of the signal.

• MeSH
• fotony * MeSH
• lidé MeSH
• neutrofily metabolismus   MeSH
• počítačová simulace MeSH
• Poissonovo rozdělení * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Poisson׳s ratio of fibrous soft tissues is analyzed in this paper on the basis of constitutive models and experimental data. Three different up-to-date constitutive models accounting for the dispersion of fibre orientations are analyzed. Their predictions of the anisotropic Poisson׳s ratios are investigated under finite strain conditions together with the effects of specific orientation distribution functions and of other parameters. The applied constitutive models predict the tendency to lower (or even negative) out-of-plane Poisson׳s ratio. New experimental data of porcine arterial layer under uniaxial tension in orthogonal directions are also presented and compared with the theoretical predictions and other literature data. The results point out the typical features of recent constitutive models with fibres concentrated in circumferential-axial plane of arterial layers and their potential inconsistence with some experimental data. The volumetric (in)compressibility of arterial tissues is also discussed as an eventual and significant factor influencing this inconsistency.

• Klíčová slova
• Anisotropy, Arterial wall mechanics, Compressibility, Constitutive modelling, Hyperfit software, Poisson׳s ratio,
• MeSH
• anizotropie MeSH
• arterie * MeSH
• biologické modely * MeSH
• biomechanika MeSH
• mechanické jevy * MeSH
• mechanický stres MeSH
• Poissonovo rozdělení MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

The aim of the study was to examine the prevalence and type of medicines used by high school students in the Czech Republic and to analyze association between use of medicines during last 6 months and self medication with different socio-demographic and lifestyle aspects. A cross-sectional study was conducted in high schools from two regions and three towns in the Czech Republic. The study sample was a student population of nine selected high schools. The study was approved by the local Ethics Committees and school board and was conducted in compliance with the ethical principles of the Declaration of Helsinki. Questionnaires respecting anonymity were distributed to the students during the regular class period. Students answered closed and open questions divided into six sections focussing on their experience with chronic and irregular use of medicines, medicines use during last six months, conditions treated, type and source of used medicines. A modified log-linear Poisson regression model with a robust variance estimator (sandwich) was used for statistical analysis. In total, 979 students, aged 14-21 years (mean age 17 years) participated in the study: 32% were male and 68% female; 19% of students reported regular use of medicines for chronic disease. The use of medicines during the last 6 months was reported by 83% of students; 42% of them reported the use of both prescription and over the counter (OTC) medicines; 22% the use only of OTC, and 31% only prescription medicines. Allergy, asthma, disorders of the thyroid gland, atopic dermatitis, and hypertensive diseases were among the most frequent long-term diseases. The most frequent groups of medicines used for the treatment of long-term diseases were systemic antihistamines, thyroid preparations, and respiratory drugs. Nonsteroidal anti-inflammatory medicines, ibuprofen and paracetamol were the most frequently used medicines during last six months. The study results showed quite extensive use of both prescription and OTC medicines in students of high schools between 14-21 years of age in the Czech Republic. Statistically significant associations were found between use of medicines during last 6 months and type of school, sex and chronic diseases, and between self-medication and sex.

• MeSH
• dospělí MeSH
• farmakoterapie * MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• Poissonovo rozdělení MeSH
• průřezové studie MeSH
• samoléčba statistika a číselné údaje   MeSH
• studenti MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH

AIM: This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. METHODS: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA25 system (version 1). A subset of 146 vaginal cancers was tested for p16(INK4a) expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. RESULTS: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in younger ages. Concerning the type-specific distribution, HPV16 was the most frequently type detected in both precancerous and cancerous lesions (59%). p16(INK4a) overexpression was found in 87% of HPV DNA positive vaginal cancer cases. CONCLUSIONS: HPV was identified in a large proportion of invasive vaginal cancers and in almost all VAIN 2/3. HPV16 was the most common type detected. A large impact in the reduction of the burden of vaginal neoplastic lesions is expected among vaccinated cohorts.

• Klíčová slova
• Human papillomavirus, Vaccine, Vaginal cancer, Vaginal intraepithelial neoplasia,
• MeSH
• DNA virů analýza   MeSH
• imunoenzymatické techniky MeSH
• infekce papilomavirem komplikace   epidemiologie   virologie   MeSH
• inhibitor p16 cyklin-dependentní kinasy metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lidský papilomavirus 16 izolace a purifikace   MeSH
• mezinárodní spolupráce MeSH
• nádory vaginy komplikace   epidemiologie   virologie   MeSH
• Papillomaviridae izolace a purifikace   MeSH
• Poissonovo rozdělení MeSH
• prekancerózy epidemiologie   virologie   MeSH
• prevalence MeSH
• průřezové studie MeSH
• regresní analýza MeSH
• retrospektivní studie MeSH
• senioři MeSH
• spinocelulární karcinom komplikace   epidemiologie   virologie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• DNA virů MeSH
• inhibitor p16 cyklin-dependentní kinasy MeSH

Leaky integrate-and-fire neuronal models with reversal potentials have a number of different diffusion approximations, each depending on the form of the amplitudes of the postsynaptic potentials. Probability distributions of the first-passage times of the membrane potential in the original model and its diffusion approximations are numerically compared in order to find which of the approximations is the most suitable one. The properties of the random amplitudes of postsynaptic potentials are discussed. It is shown on a simple example that the quality of the approximation depends directly on them.

• MeSH
• akční potenciály fyziologie   MeSH
• difuze MeSH
• lidé MeSH
• matematika MeSH
• membránové potenciály fyziologie   MeSH
• modely neurologické * MeSH
• neurony fyziologie   MeSH
• normální rozdělení MeSH
• počítačová simulace MeSH
• Poissonovo rozdělení MeSH
• pravděpodobnost MeSH
• stochastické procesy MeSH
• synaptické potenciály MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Fano factor is one of the most widely used measures of variability of spike trains. Its standard estimator is the ratio of sample variance to sample mean of spike counts observed in a time window and the quality of the estimator strongly depends on the length of the window. We investigate this dependence under the assumption that the spike train behaves as an equilibrium renewal process. It is shown what characteristics of the spike train have large effect on the estimator bias. Namely, the effect of refractory period is analytically evaluated. Next, we create an approximate asymptotic formula for the mean square error of the estimator, which can also be used to find minimum of the error in estimation from single spike trains. The accuracy of the Fano factor estimator is compared with the accuracy of the estimator based on the squared coefficient of variation. All the results are illustrated for spike trains with gamma and inverse Gaussian probability distributions of interspike intervals. Finally, we discuss possibilities of how to select a suitable observation window for the Fano factor estimation.

• MeSH
• akční potenciály fyziologie   MeSH
• algoritmy MeSH
• lidé MeSH
• modely neurologické MeSH
• neurony metabolismus   fyziologie   MeSH
• normální rozdělení MeSH
• Poissonovo rozdělení MeSH
• pravděpodobnost MeSH
• reprodukovatelnost výsledků MeSH
• teoretické modely MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH