OBJECTIVE: The objective of this study is to determinate the influence of oligohydramnios on perinatal outcome in term pregnancies. DESIGN: Retrospective case-control study. SETTING: II. Gynecologic Obstetrics Department, Comenius University, Bratislava. METHODS: Authors analysed a group of 372 single pregnancies after completed 37th week of gestation in years 2011 to 2015 with sonographic diagnosis of isolated oligohydramnios. A control group was created with matched patients by age and parity with normal amniotic fluid volume. RESULTS: We found significant differences in number of obstetric intervention between the two groups: patients with oligohydramnios had higher number of cesarean sections (71% compared to 33.9% in control group) and also the number of inductions was significantely higher (27.4% compared to 18.8%). The most common indication for cesarean delivery was presumed fetal hypoxia. We did not find any differences in numbers of neonates with low Apgar score, low umbilical cord pH and admission to neonatal intensive care unit. CONCLUSION: The finding of isolated oligohydramnios after 37th week of gestations is associated with higher risk of obstetric intervention without any association with adverse perinatal outcome.

• Klíčová slova
• amniotic fluid, cesarean section perinatal mortality., oligohydramnios, perinatal outcome,
• MeSH
• císařský řez statistika a číselné údaje   MeSH
• dospělí MeSH
• indukovaný porod statistika a číselné údaje   MeSH
• lidé MeSH
• novorozenec MeSH
• oligohydramnion diagnostické zobrazování   MeSH
• plodová voda metabolismus   MeSH
• retrospektivní studie MeSH
• studie případů a kontrol MeSH
• těhotenství MeSH
• třetí trimestr těhotenství MeSH
• ultrasonografie MeSH
• výsledek těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The case report focuses on the case of heavy Graves - Basedow thyreotoxicosis in 33 years old secundipara who was transferred to our departement from regional hospital for decompensation of gestational hypertension, oligohydramnios and the suspition on intrauterine growth restriction (IUGR). In our clinical praxis the problems of thyroid gland in terms of its reduced function in pregnant women are getting more frequent. The goal of this article is to describe the less often situation, the hyperthyroidism in the third trimestr of the pregnancy. Thyretoxicosis in pregnancy is associated with higher risk of preterm labour, preeclampsia, IUGR, heart failure and stillbirth. Some of these complications confirmes our case report.

• Klíčová slova
• hyperthyroidism., pregnancy, thyreotoxicosis,
• MeSH
• dospělí MeSH
• hypertenze indukovaná těhotenstvím * MeSH
• hypertyreóza * MeSH
• komplikace těhotenství * MeSH
• lidé MeSH
• narození mrtvého plodu MeSH
• novorozenec MeSH
• oligohydramnion * MeSH
• předčasná porodní činnost MeSH
• preeklampsie MeSH
• růstová retardace plodu * MeSH
• těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

OBJECTIVE: To determine the association between the presence of oligohydramnios, determined as an amniotic fluid index ≤ 5 cm and the intra-amniotic inflammatory response, fetal inflammatory response and neonatal outcomes in actively managed preterm prelabor rupture of membranes (PPROM). METHODS: Women with singleton pregnancies complicated by PPROM at a gestational age of between 24+0 and 36+6 weeks were included in the study. Ultrasound assessments of the amniotic fluid index and evaluation of the amniotic fluid interleukin (IL)-6 levels were performed at admission. The umbilical cord blood IL-6 levels were evaluated after delivery. RESULTS: In total, 74 women were included. The women with oligohydramnios did not have different amniotic fluid IL-6 levels [with oligohydramnios: median 342 pg/mL, interquartile range (IQR) 110-1809 vs. without oligohydramnios: median 256 pg/mL, IQR 122-748; p = 0.71] or umbilical cord blood IL-6 levels (with oligohydramnios: median 8.2 pg/mL, IQR 3.8-146.9 vs. without oligohydramnios: median 5.9 pg/mL, IQR 2.1-27.9; p = 0.14) than those without oligohydramnios. No association between oligohydramnios and neonatal morbidity was found. A correlation between the amniotic fluid index and the interval from rupture of membranes to amniocentesis was observed (rho = -0.34; p = 0.003). CONCLUSION: The presence of oligohydramnios is not associated with an adverse outcome in actively managed PPROM in singleton pregnancies in the absence of other complications.

• MeSH
• chorioamnionitida patofyziologie   MeSH
• dospělí MeSH
• fetální krev metabolismus   MeSH
• gestační stáří MeSH
• interleukin-6 metabolismus   MeSH
• kojenec MeSH
• lidé MeSH
• nemoci nedonošenců diagnóza   patofyziologie   MeSH
• novorozenec nedonošený MeSH
• novorozenec MeSH
• oligohydramnion patofyziologie   MeSH
• plodová voda metabolismus   MeSH
• předčasná porodní činnost MeSH
• předčasný odtok plodové vody patofyziologie   MeSH
• předčasný porod MeSH
• prospektivní studie MeSH
• těhotenství MeSH
• ultrasonografie prenatální MeSH
• výsledek těhotenství * MeSH
• Check Tag
• dospělí MeSH
• kojenec MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• interleukin-6 MeSH

OBJECTIVES: Enterolithiasis (multiple calcifications of intraluminal meconium) is a rare, prenatal ultrasonographic finding. In this study, our aim was to evaluate the prenatal diagnostic features and discuss the management of the patients. METHODS: The data of two cases of prenatally diagnosed fetal enterolithiasis were collected from ultrasound scan, magnetic resonance imaging (MRI) and neonatal or postnatal autopsy records. The findings were evaluated in both prenatal and postnatal periods. Chromosomal analysis was performed in one case. An evaluation of primary and secondary malformations was done. Coexisting anomalies were searched for via radiology, neonatal surgery and histopathology. RESULTS: Malformations in two cases (both males) with partial and complete urorectal septum malformation (URSM) sequence were described. The absence of an anal opening and presence of a fistula between the urinary and gastrointestinal tract were common findings. These features were considered as primary malformations contributing to the formation of enterolithiasis. Secondary anomalies (urinary and gastrointestinal system malformations, pulmonary hypoplasia, genital and other coexisting anomalies) were evaluated. CONCLUSIONS: The prenatal detection of enterolithiasis carries a poor prognosis. Most of the previously reported cases were invariably associated with major fetal malformations of the urinary and gastrointestinal tract. It is a warning sign for large bowel obstruction with or without enterourinary fistula. Therefore, adequate gastrointestinal and urologic studies must be undertaken after birth for the final diagnosis. There is a high mortality rate in the reported cases, mostly attributed to associated anomalies, and all survivors required neonatal surgery. It is important to differentiate the partial from the full URSM sequence because the prognosis in the partial URSM sequence is generally good, with long-term survival being common.

• MeSH
• dospělí MeSH
• kalcinóza diagnóza   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mekonium chemie   diagnostické zobrazování   MeSH
• močové ústrojí abnormality   MeSH
• nemoci plodu diagnóza   diagnostické zobrazování   MeSH
• nemoci střev diagnóza   MeSH
• nemoci u dvojčat diagnóza   diagnostické zobrazování   MeSH
• oligohydramnion diagnostické zobrazování   MeSH
• prenatální diagnóza * MeSH
• rektum abnormality   MeSH
• střeva abnormality   MeSH
• těhotenství MeSH
• ultrasonografie prenatální MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH