INTRODUCTION: Robotic pancreaticoduodenectomy ranks among the routinely performed surgical procedures in world pancreatic centres. Since 2023, it has also been performed in the Czech Republic. CASE REPORT: We present a case of a 65-year-old patient with accidentally found dilatation of the pancreatic duct. During the examination, a small tumor in the head of the pancreas was diagnosed. A robotic pancreaticoduodenectomy was performed. Due to the perioperative suspicion of invasion into the portal vein, the resection was performed. The operation and the course of hospitalization were uncomplicated, the patient was discharged on the 9th postoperative day. CONCLUSION: Robotic pancreaticoduodenectomy is a method that combines the advantages of a minimally invasive approach and meets the requirements for safety and oncological radicality. Suspected venous invasion is not an obstacle to completing robotic surgery.
- Klíčová slova
- PDE, Pancreatic cancer, Whipple, mini-invasive pancreatic surgery, pancreatic cancer, robotic pancreaticoduodenectomy,
- MeSH
- lidé MeSH
- nádory slinivky břišní * chirurgie patologie MeSH
- pankreatoduodenektomie * metody MeSH
- roboticky asistované výkony * MeSH
- senioři MeSH
- vena portae * chirurgie MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
BACKGROUND: Isolated injury to the superior mesenteric vein (SMV) caused by blunt abdominal trauma is rare but often lethal, especially in pediatric patients. Due to the low incidence of SMV injuries, there are no universal guidelines for its diagnosis and treatment. The diagnosis is made using either computed tomography (CT) or intraoperative exploration. Primary vascular repair is recommended. CASE REPORT: A 10-year-old girl was transferred to a trauma center after a high-energy motor vehicle collision. Under the diagnosis of acute abdomen with hemoperitoneum, the patient underwent urgent laparotomy, 34 min after admission to the hospital. A complete laceration of the SMV trunk was observed. Definitive vascular repair of the transected SMV was performed. An interposition graft from the internal jugular vein was used with a good postoperative course. CONCLUSION: This case report demonstrates that definitive vascular repair of the SMV reduces the risk of intestinal ischemia and should be performed in cases where ligation presents a real threat to small bowel viability. In cases of severe SMV injury, the internal jugular vein is a high-quality and easily accessible graft.
- Klíčová slova
- Pediatric patient, definitive vascular repair, internal jugular vein, trauma of the superior mesenteric vein,
- MeSH
- dítě MeSH
- dopravní nehody MeSH
- lacerace * chirurgie etiologie MeSH
- laparotomie metody MeSH
- lidé MeSH
- počítačová rentgenová tomografie MeSH
- poranění břicha * komplikace chirurgie diagnóza MeSH
- poranění cév * chirurgie etiologie diagnóza MeSH
- tupá poranění * komplikace chirurgie diagnóza MeSH
- vena mesenterica * zranění chirurgie diagnostické zobrazování MeSH
- výkony cévní chirurgie metody MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
INTRODUCTION: As liver disease progresses, scarring results in worsening hemodynamics ultimately culminating in portal hypertension. This process has classically been quantified through the portosystemic pressure gradient (PSG), which is clinically estimated by hepatic venous pressure gradient (HVPG); however, PSG alone does not predict a given patient's clinical trajectory regarding the Baveno stage of cirrhosis. We hypothesize that a patient's PSG sensitivity to venous remodeling could explain disparate disease trajectories. METHODS: We created a computational model of the portal system in the context of worsening liver disease informed by physiologic measurements from the field of portal hypertension. We simulated progression of clinical complications, HVPG, and transjugular intrahepatic portosystemic shunt placement while only varying a patient's likelihood of portal venous remodeling. RESULTS: Our results unify hemodynamics, venous remodeling, and the clinical progression of liver disease into a mathematically consistent model of portal hypertension. We find that by varying how sensitive patients are to create venous collaterals with rising PSG we can explain variation in patterns of decompensation for patients with liver disease. Specifically, we find that patients who have higher proportions of portosystemic shunting earlier in disease have an attenuated rise in HVPG, delayed onset of ascites, and less hemodynamic shifting after transjugular intrahepatic portosystemic shunt placement. DISCUSSION: This article builds a computational model of portal hypertension which supports that patient-level differences in venous remodeling may explain disparate clinical trajectories of disease.
INTRODUCTION: Portomesenteric vein resections are a well-established part of pancreatectomies for advanced tumors that invade the portomesenteric axis. There are two main types of portomesenteric resections: partial resections, where only part of the venous wall is removed and segmental resection, where the full circumference of the wall is removed. The aim of this study is to compare short-term and long-term outcomes between these two techniques. METHODS: This is a single-centre retrospective study of the patients with pancreatic cancer who underwent pancreatectomy with portomesenteric vein resections between November 2009 and May 2021. RESULTS: From a total of 773 pancreatic cancer procedures, 43 (6%) patients underwent pancreatectomy with portomesenteric resections: 17 partial and 26 segmental. The overall median survival was 11 mo. For the partial portomesenteric resections, the median survival was 29 mo, and for the segmental portomesenteric resections, it was 10 mo (P = 0.019). The primary patency of the reconstructed veins after partial resection was 100% and after segmental resection was 92% (P = 0.220). Negative resection margins were achieved in 13 patients (76%) who underwent partial portomesenteric vein resection and 23 patients (88%) who underwent segmental portomesenteric vein resection. CONCLUSIONS: |Although this study is associated with worse survival, segmental resection is often the only way to safely remove pancreatic tumors with negative resection margins.
- Klíčová slova
- Oncovascular surgery, Pancreatectomy, Pancreatic cancer, Portomesenteric vein,
- MeSH
- lidé MeSH
- nádory slinivky břišní * patologie MeSH
- pankreatektomie * metody MeSH
- resekční okraje MeSH
- retrospektivní studie MeSH
- vena mesenterica chirurgie MeSH
- vena portae chirurgie patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND & AIMS: Complex portal vein thrombosis (PVT) is a challenge in liver transplantation (LT). Extra-anatomical approaches to portal revascularization, including renoportal (RPA), left gastric vein (LGA), pericholedochal vein (PCA), and cavoportal (CPA) anastomoses, have been described in case reports and series. The RP4LT Collaborative was created to record cases of alternative portal revascularization performed for complex PVT. METHODS: An international, observational web registry was launched in 2020. Cases of complex PVT undergoing first LT performed with RPA, LGA, PCA, or CPA were recorded and updated through 12/2021. RESULTS: A total of 140 cases were available for analysis: 74 RPA, 18 LGA, 20 PCA, and 28 CPA. Transplants were primarily performed with whole livers (98%) in recipients with median (IQR) age 58 (49-63) years, model for end-stage liver disease score 17 (14-24), and cold ischemia 431 (360-505) minutes. Post-operatively, 49% of recipients developed acute kidney injury, 16% diuretic-responsive ascites, 9% refractory ascites (29% with CPA, p <0.001), and 10% variceal hemorrhage (25% with CPA, p = 0.002). After a median follow-up of 22 (4-67) months, patient and graft 1-/3-/5-year survival rates were 71/67/61% and 69/63/57%, respectively. On multivariate Cox proportional hazards analysis, the only factor significantly and independently associated with all-cause graft loss was non-physiological portal vein reconstruction in which all graft portal inflow arose from recipient systemic circulation (hazard ratio 6.639, 95% CI 2.159-20.422, p = 0.001). CONCLUSIONS: Alternative forms of portal vein anastomosis achieving physiological portal inflow (i.e., at least some recipient splanchnic blood flow reaching transplant graft) offer acceptable post-transplant results in LT candidates with complex PVT. On the contrary, non-physiological portal vein anastomoses fail to resolve portal hypertension and should not be performed. IMPACT AND IMPLICATIONS: Complex portal vein thrombosis (PVT) is a challenge in liver transplantation. Results of this international, multicenter analysis may be used to guide clinical decisions in transplant candidates with complex PVT. Extra-anatomical portal vein anastomoses that allow for at least some recipient splanchnic blood flow to the transplant allograft offer acceptable results. On the other hand, anastomoses that deliver only systemic blood flow to the allograft fail to resolve portal hypertension and should not be performed.
- Klíčová slova
- cavoportal anastomosis, cavoportal hemitransposition, liver transplantation, multivisceral transplantation, portal hypertension, portal vein thrombosis, renoportal anastomosis,
- MeSH
- ascites komplikace MeSH
- ezofageální a žaludeční varixy * komplikace MeSH
- gastrointestinální krvácení MeSH
- konečné stadium selhání jater * komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- portální hypertenze * komplikace chirurgie MeSH
- stupeň závažnosti nemoci MeSH
- transplantace jater * metody MeSH
- vena portae chirurgie MeSH
- žilní trombóza * etiologie chirurgie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND/AIM: Portal vein embolization (PVE) with autologous stem cells application (aHSC) is a method for future liver remnant volume (FLRV) increase. The aim of the study was to evaluate the positivite and negativite aspects of the method in clinical practice. PATIENTS AND METHODS: PVE with aHSC application was used in 32 patients with colorectal liver metastases and insufficient FLRV. Preoperative number of colorectal liver metastases (CLMs) was 5.2±3.6, CLMs volume 70.1±102.3 mm3 Results: FLRV growth occurred after 2-3 weeks in 31 (96.9%) patients, with volume increase from 528.2±170.5 to 715.4±143.3 ml (p=0.0001). Postoperative thirty days mortality, morbidity was 0% and 3.1%, respectively. Insufficient FLRV growth occurred in one patient. R0 liver resection was performed in 27(87.1%) patients. CLMs volume progression was in 5 (15.6%) patients from 680.0±59.4 to 723.1±57.1 ml (p=0.01). One and two-year overall survival were 88% and 62.9% respectively. Six and twelve-month recurrence-free survival rates were 50.7% and 39.6% respectively. CONCLUSION: PVE with aHSC application is a safe and useful method for FLRV growth. It significantly increases secondary CLMs resectability. However, it can cause CLMs progression. Liver resection should, therefore, be performed as soon as possible after achieving optimal increase of FLRV.
- Klíčová slova
- Colorectal liver metastases, future liver remnant volume, portal vein embolization, stem cells, tumour stimulation,
- MeSH
- hematopoetické kmenové buňky MeSH
- hepatektomie škodlivé účinky MeSH
- kolorektální nádory * MeSH
- lidé MeSH
- nádory jater * chirurgie MeSH
- předoperační péče MeSH
- terapeutická embolizace * škodlivé účinky MeSH
- vena portae chirurgie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: ALPPS is found to increase the resectability of primary and secondary liver malignancy at the advanced stage. The aim of the study was to verify the surgical and oncological outcome of ALPPS for intrahepatic cholangiocarcinoma (ICC). METHODS: The study cohort was based on the ALPPS registry with patients from 31 international centers between August 2009 and January 2018. Propensity score matched patients receiving chemotherapy only were selected from the SEER database as controls for the survival analysis. RESULTS: One hundred and two patients undergoing ALPPS were recruited, 99 completed the second stage with median inter-stage duration of 11 days. The median kinetic growth rate was 23 ml/day. R0 resection was achieved in 87 (85%). Initially high rates of morbidity and mortality decreased steadily to a 29% severe complication rate and 7% 90-day morbidity in the last 2 years. Post-hepatectomy liver failure remained the main cause of 90-day mortality. Multivariate analysis revealed insufficient future liver remnant at the stage-2 operation (FLR2) to be the only risk factor for severe complications (OR 2.91, p = 0.02). The propensity score matching analysis showed a superior overall survival in the ALPPS group compared to palliative chemotherapy (median overall survival: 26.4 months vs 14 months; 1-, 2-, and 3-year survival rates: 82.4%, 70.5% and 39.6% vs 51.2%, 21.4% and 11.3%, respectively, p < 0.01). The survival benefit, however, was not confirmed in the subgroup analysis for patients with insufficient FLR2 or multifocal ICC. CONCLUSION: ALPPS showed high efficacy in achieving R0 resections in locally advanced ICC. To get the most oncological benefit from this aggressive surgery, ALPPS would be restricted to patients with single lesions and sufficient FLR2.
- MeSH
- ascites epidemiologie MeSH
- cholangiokarcinom chirurgie MeSH
- dospělí MeSH
- hepatektomie metody MeSH
- infekce chirurgické rány epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- ligace MeSH
- mezinárodní spolupráce MeSH
- míra přežití MeSH
- nádory žlučových cest chirurgie MeSH
- paliativní péče MeSH
- pooperační komplikace epidemiologie prevence a kontrola MeSH
- pooperační krvácení epidemiologie MeSH
- program SEER MeSH
- proporcionální rizikové modely MeSH
- protinádorové látky terapeutické užití MeSH
- registrace MeSH
- selhání jater prevence a kontrola MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tendenční skóre MeSH
- vena portae chirurgie MeSH
- výsledek terapie MeSH
- žlučové cesty intrahepatální * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Názvy látek
- protinádorové látky MeSH
BACKGROUND: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. MATERIALS AND METHODS: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. RESULTS: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. CONCLUSION: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.
- Klíčová slova
- Pancreaticoduodenectomy, allogeneic grafts, computer blood flow simulation, portal vein haemodynamics, portal vein reconstruction,
- MeSH
- alografty MeSH
- anastomóza chirurgická metody MeSH
- hemodynamika MeSH
- léčba šetřící orgány MeSH
- mrtvola MeSH
- odběr tkání a orgánů MeSH
- pankreatoduodenektomie * MeSH
- počítačová simulace * MeSH
- pooperační komplikace etiologie MeSH
- prasata MeSH
- pylorus MeSH
- regionální krevní průtok MeSH
- ultrasonografie MeSH
- velikost orgánu MeSH
- vena cava inferior anatomie a histologie diagnostické zobrazování fyziologie transplantace MeSH
- vena portae anatomie a histologie diagnostické zobrazování fyziologie chirurgie MeSH
- zákroky plastické chirurgie metody MeSH
- žilní trombóza etiologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
Background: Portal vein thrombosis (PVT) is a partial or complete thrombotic occlusion of the portal vein and is rare in noncirrhotic patients.Patients and methods: 78 adult patients with noncirrhotic acute PVT without known malignity were evaluated. Patients with initial CRP level 61-149 mg/l were excluded.Results: Patients were divided into two groups - the first one (33 patients) was characterized with signs of inflammation and CRP over 149 mg/l. The second group (45 patients) was without signs of inflammation and CRP level less than 61 mg/l. The frequency of prothrombotic hematologic factors was statistically significantly different in levels of factor VIII and MTHFR 677 C mutation. All patients from both groups underwent the same oncologic and hemato-oncologic screening which was positive in 23 patients (51.1%) in the group without signs of inflammation. In the group of patients with clinical and laboratory signs of inflammation oncologic and hemato-oncologic screening was positive only in 1 patient (3.0%). Complete portal vein recanalization was achieved in 19.2%, partial recanalization in 26.9%.Conclusions: Patients with clinical signs of inflammation and acute PVT have a low risk of malignancy in contrast to patients without signs of inflammation and acute PVT, which have a high risk of oncologic or hemato-oncologic disease. Patients with negative hemato-oncologic screening should be carefully observed over time because we expect they are at higher risk for the development of hemato-oncologic disease, independent from the presence and number of procoagulation risk factors.
- Klíčová slova
- Acute portal vein thrombosis, hemato-oncologic disease, prothrombotic factors,
- MeSH
- akutní nemoc MeSH
- biologické markery krev MeSH
- C-reaktivní protein analýza MeSH
- časové faktory MeSH
- lidé středního věku MeSH
- lidé MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- vena portae * MeSH
- zánět krev MeSH
- žilní trombóza krev diagnóza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- srovnávací studie MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
INTRODUCTION: The umbilical vein can become recanalised due to portal hypertension in patients with liver cirrhosis but the condition is rarely clinically significant. Although bleeding from this enlarged vein is a known complication, the finding of thrombophlebitis has not been previously described. CASE REPORT: We report the case of a 62-year-old male with a history of liver cirrhosis due to alcoholic liver disease presenting to hospital with epigastric pain. A CT scan of the patients abdomen revealed a thrombus with surrounding inflammatory changes in a recanalised umbilical vein. The patient was managed conservatively and was discharged home the following day. CONCLUSION: Thrombophlebitis of a recanalised umbilical vein is a rare cause of abdominal pain in patients with liver cirrhosis.
- Klíčová slova
- liver cirrhosis, thrombophlebitis, umbilical vein,
- MeSH
- bolesti břicha * diagnostické zobrazování etiologie MeSH
- krvácení MeSH
- lidé středního věku MeSH
- lidé MeSH
- počítačová rentgenová tomografie MeSH
- tromboflebitida * komplikace MeSH
- vena portae MeSH
- venae umbilicales * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
