Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80-90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.

• Klíčová slova
• PLGA with papaverine hydrochloride coatings, break strength, dynamic frictional force, radiopacity, retention strength, ureteral stent,
• MeSH
• biokompatibilní materiály farmakologie   MeSH
• kopolymer kyseliny glykolové a mléčné farmakologie   MeSH
• lidé MeSH
• obstrukce močovodu metabolismus   chirurgie   terapie   MeSH
• papaverin metabolismus   farmakologie   MeSH
• polyurethany chemie   MeSH
• stenty uvolňující léky * MeSH
• vstřebatelné implantáty MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biokompatibilní materiály MeSH
• kopolymer kyseliny glykolové a mléčné MeSH
• papaverin MeSH
• polyurethany MeSH

• MeSH
• adrenalin aplikace a dávkování   farmakologie   MeSH
• fenoxybenzamin aplikace a dávkování   farmakologie   MeSH
• jaterní oběh účinky léků   MeSH
• játra účinky léků   metabolismus   MeSH
• králíci MeSH
• papaverin aplikace a dávkování   farmakologie   MeSH
• spotřeba kyslíku účinky léků   MeSH
• vazodilatancia * MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• adrenalin MeSH
• fenoxybenzamin MeSH
• papaverin MeSH
• vazodilatancia * MeSH

• MeSH
• adrenalin farmakologie   MeSH
• aminopyrin analogy a deriváty   MeSH
• fenoxybenzamin aplikace a dávkování   farmakologie   MeSH
• fixní kombinace léků aplikace a dávkování   farmakologie   MeSH
• jaterní oběh účinky léků   MeSH
• játra metabolismus   MeSH
• králíci MeSH
• metamizol aplikace a dávkování   farmakologie   MeSH
• papaverin aplikace a dávkování   farmakologie   MeSH
• pyrazoly aplikace a dávkování   farmakologie   MeSH
• spotřeba kyslíku účinky léků   MeSH
• tropany aplikace a dávkování   farmakologie   MeSH
• vazodilatancia * MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• adrenalin MeSH
• aminopyrin MeSH
• fenoxybenzamin MeSH
• fixní kombinace léků MeSH
• metamizol MeSH
• Palerol MeSH Prohlížeč
• papaverin MeSH
• pyrazoly MeSH
• tropany MeSH
• vazodilatancia * MeSH

The study was aimed to compare the effects of pentoxyphylline, aminophylline, choline theophyllinate and ethymizol on guinea pig and dog trachea with those of theophylline, papaverine and ephedrine. The effects of these drugs on the basal tension, on dose-response curves for muscle contraction produced by histamine and on cAMP level were investigated in guinea pig trachea, together with their influence on the resting and histamine-evoked mechanical and membrane activities of dog trachea. Like papaverine, pentoxyphylline did not alter the resting membrane potential, although it relaxed both tracheal preparations, and it antagonised the effects histamine and raised the cAMP level of the smooth muscle. The effects of ethymizol were similar to those of theophylline and its water soluble derivatives (aminophylline and choline theophyllinate). Whereas, ephedrine although it decreased the basal tension and inhibited histamine-evoked responses, also elicited substantial hyperpolarization of the smooth muscle membrane with no effect on the cAMP level. These findings are consistent with the hypothesis that cAMP has an important role in the action of some bronchodilator drugs; however, it is concluded that the possibility of contributing of their action on membrane potential to their action needs to be considered. The similarity of the potencies of ethymizol and pentoxyphylline to that of classical bronchodilators in inhibiting contraction of guinea pig and dog tracheal smooth muscle suggests that they may have a therapeutic value.

• MeSH
• AMP cyklický metabolismus   MeSH
• bronchodilatancia farmakologie   MeSH
• efedrin farmakologie   MeSH
• etimizol farmakologie   MeSH
• histamin farmakologie   MeSH
• inhibitory fosfodiesteras farmakologie   MeSH
• morčata MeSH
• papaverin farmakologie   MeSH
• psi MeSH
• relaxace svalu účinky léků   MeSH
• techniky in vitro MeSH
• trachea účinky léků   fyziologie   MeSH
• xanthiny farmakologie   MeSH
• zvířata MeSH
• Check Tag
• morčata MeSH
• mužské pohlaví MeSH
• psi MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• AMP cyklický MeSH
• bronchodilatancia MeSH
• efedrin MeSH
• etimizol MeSH
• histamin MeSH
• inhibitory fosfodiesteras MeSH
• methylxanthine MeSH Prohlížeč
• papaverin MeSH
• xanthiny MeSH

The development of rat myocardial lesion induced by isoprenaline was studied under the influence of Faustan, morphine and Spasmo-eunalgit. A protective effect diminishing the myocardial lesion was limited to morphine.

• MeSH
• aminopyrin farmakologie   MeSH
• barbituráty farmakologie   MeSH
• diazepam farmakologie   MeSH
• fixní kombinace léků farmakologie   MeSH
• inbrední kmeny potkanů MeSH
• isoprenalin toxicita   MeSH
• krysa rodu Rattus MeSH
• morfin farmakologie   MeSH
• myokard cytologie   MeSH
• papaverin farmakologie   MeSH
• rostlinné extrakty farmakologie   MeSH
• srdce účinky léků   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• aminopyrin MeSH
• barbituráty MeSH
• diazepam MeSH
• fixní kombinace léků MeSH
• isoprenalin MeSH
• morfin MeSH
• papaverin MeSH
• rostlinné extrakty MeSH
• spasmo-eunalgit MeSH Prohlížeč

The ramus interventricularis ventralis (RIV) of the dog heart was perfused with donor blood from the femoral artery. The inflow and outflow pressure, the blood flow and the diameter of the RIV were recorded. An increase in the blood flow from 11.3 +/- 0.3 to 81.4 +/- 6.2 ml/min induced, in 24.4 +/- 1.7 s a gradual increase in RIV diameter which became stabilized in 90-120 s and amounted to 80.87 +/- 11.68 microns, i.e. to 3.37 +/- 0.70% of the resting diameter. Since the mean pressure at the site where the diameter was recorded was maintained constant, relaxation of RIV smooth muscle has been assumed to have occurred. Dilation could not be evoked after RIV had been dilated by papaverine. Any interference by changes in pressure amplitude accompanying the increase in blood flow was precluded by using non-pulsating perfusion of the RIV. An increase in the non-pulsating blood flow from 12.11 +/- 2.20 to 90.33 +/- 11.30 ml/min likewise--in 19.50 +/- 1.83 s--produced an increase in RIV diameter of 1.8%. Blood flow is being suggested as one factor regulating the tone of the smooth muscle of the major coronary artery. This mechanism is supposed to counteract sympathetic constriction of the major coronary artery.

• MeSH
• koronární cévy fyziologie   MeSH
• koronární cirkulace * MeSH
• papaverin farmakologie   MeSH
• psi MeSH
• vazodilatace * MeSH
• zvířata MeSH
• Check Tag
• psi MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• papaverin MeSH

• MeSH
• chlorpromazin farmakologie   MeSH
• cholinesterasové inhibitory farmakologie   MeSH
• fosfodiesterasy krev   MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• organothiofosfáty farmakologie   MeSH
• papaverin farmakologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chlorpromazin MeSH
• cholinesterasové inhibitory MeSH
• fosfodiesterasy MeSH
• O-ethyl S-(2-dimethylaminoethyl) methylphosphonothioate MeSH Prohlížeč
• organothiofosfáty MeSH
• papaverin MeSH

• MeSH
• adrenalin farmakologie   MeSH
• dipyridamol farmakologie   MeSH
• fixní kombinace léků farmakologie   MeSH
• glukagon farmakologie   MeSH
• jaterní oběh účinky léků   MeSH
• králíci MeSH
• metamizol farmakologie   MeSH
• mikrocirkulace účinky léků   MeSH
• papaverin farmakologie   MeSH
• perfuze MeSH
• pyrazoly farmakologie   MeSH
• theofylin farmakologie   MeSH
• transplantace jater MeSH
• tropany farmakologie   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adrenalin MeSH
• dipyridamol MeSH
• fixní kombinace léků MeSH
• glukagon MeSH
• metamizol MeSH
• Palerol MeSH Prohlížeč
• papaverin MeSH
• pyrazoly MeSH
• theofylin MeSH
• tropany MeSH

• MeSH
• hexamethoniové sloučeniny farmakologie   MeSH
• kontrakce myokardu účinky léků   MeSH
• nervus vagus účinky léků   fyziologie   MeSH
• nikotinové receptory účinky léků   MeSH
• papaverin farmakologie   MeSH
• Rana esculenta MeSH
• receptory cholinergní účinky léků   MeSH
• srdeční frekvence účinky léků   MeSH
• žáby MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• hexamethoniové sloučeniny MeSH
• nikotinové receptory MeSH
• papaverin MeSH
• receptory cholinergní MeSH

Electrical and mechanical activity of smooth muscle of the guinea-pig caecum was recorded by means of the sucrose-gap technique. The responses of longitudinal and circular smooth muscle to acetycholine were differently affected by changes of extracellular calcium concentration (0.8, 2.5 and 7.5 mM). The contractions of both preparations were depressed at high Ca++ concentrations, whereas at low Ca++ concentrations only contractions of the circular smooth muscle were augmented. The stimulatory effect of acetylcholine was decreased by papaverine in both preparations at all three concentrations of Ca++. This inhibition was the greater the lower the concentration of extracellular Ca++ and this process was more pronounced in the circular muscle. The ability of papaverine to counteract the effect of lowered concentrations of extracellular Ca++ on membrane excitability may well explain its inhibitory effect upon intestinal smooth muscle.

• MeSH
• cékum * MeSH
• extracelulární prostor metabolismus   MeSH
• hladké svalstvo účinky léků   MeSH
• morčata MeSH
• papaverin farmakologie   MeSH
• svalová kontrakce účinky léků   MeSH
• vápník metabolismus   MeSH
• zvířata MeSH
• Check Tag
• morčata MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• papaverin MeSH
• vápník MeSH