Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) is a recently proposed lipomatous entity. HFLL was originally suggested to be a benign reactive lesion arising due to an antecedent trauma. We report two patients with HFLL who also suffered from chronic vein insufficiency due to varicose involving deep veins of the low limbs. Both patients were middle-aged women with solitary, poorly circumscribed subcutaneous lesions on the lower extremities. Histopathological examination revealed typical features of HFLL. We think that the consistent clinical features such as advanced age, female sex predilection, and specific location along with distinctive histopathological features allow the suggestion that impaired blood circulation, to wit, venous stasis is involved in the pathogenesis of HFLL. We hypothesize that the proliferation of spindled fibroblastic and myofibroblastic cells and capillaries, erythrocyte extravasation, and hemosiderin deposition with lipomatous tissue of HFLL may simply represent an exaggerated tissue response to venous stasis in which elevated venous and capillary pressures, oxygen saturation, and edema stimulate the proliferation of the above mentioned elements and lead to erythrocyte extravasation. A similar histopathological pattern is seen in acroangiodermatitis of Mali and vascular transformation of lymph node sinuses, and these conditions are also associated with impaired blood circulation.

• MeSH
• hemosiderin analýza   MeSH
• hemosideróza komplikace   patologie   chirurgie   MeSH
• histiocytóza komplikace   patologie   chirurgie   MeSH
• imunohistochemie MeSH
• lidé středního věku MeSH
• lidé MeSH
• lipom komplikace   patologie   chirurgie   MeSH
• nádorové biomarkery analýza   MeSH
• nádory měkkých tkání komplikace   patologie   chirurgie   MeSH
• tuková tkáň chemie   patologie   MeSH
• varixy komplikace   patologie   chirurgie   MeSH
• výsledek terapie MeSH
• žilní insuficience komplikace   patologie   chirurgie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• hemosiderin MeSH
• nádorové biomarkery MeSH

BACKGROUND: Nuchal-type fibroma (NTF) usually arises in the posterior aspect of the neck. Previously published reports describe only 11 cases and provide limited clinicopathologic information. METHODS: Fifty-two examples of NTF from 50 patients were analyzed from the files of the Soft Tissue Registries of the Armed Forces Institute of Pathology in Washington, DC, and the Faculty Hospital in Pilsen, Czech Republic. RESULTS: The age of the patients ranged from 3 to 74 years (mean, 40 years). There were 41 males and 9 females. Thirty-six NTFs were located in the posterior neck region and 16 were from extranuchal sites. Two patients had had lesions excised from both a nuchal and an extranuchal location. The mean greatest tumor dimension was 3.2 cm. Microscopically, all examples had a superficial (subcutaneous and sometimes dermal) component and consisted of paucicellular, thick bundles of lobulated collagen fibers with inconspicuous fibroblasts. Entrapped adipose tissue and traumatic neuromalike nerve proliferations were typically present. Skeletal muscle infiltration was also seen in a minority of cases. Eleven of 25 patients (44%) for whom clinical information was available reportedly had diabetes. Gardner's syndrome was documented in one patient and was possibly present in two additional individuals. During follow-up, five patients had local recurrences, but none of the recurrences were destructive and all were ultimately controlled by local reexcision. CONCLUSIONS: NTF is a rare, tumorlike accumulation of collagen that often affects the posterior neck region but can also occur in a number of other sites. The process has a strong association with diabetes and also appears to be linked to Gardner's syndrome. Local recurrence probably reflects the persistence of local or systemic factors related to its pathogenesis.

• MeSH
• dítě MeSH
• dospělí MeSH
• fibrom komplikace   patologie   MeSH
• Gardnerův syndrom komplikace   MeSH
• komplikace diabetu MeSH
• lidé středního věku MeSH
• lidé MeSH
• lokální recidiva nádoru MeSH
• mladiství MeSH
• nádory hlavy a krku komplikace   patologie   MeSH
• nádory měkkých tkání komplikace   patologie   MeSH
• následné studie MeSH
• předškolní dítě MeSH
• senioři MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

IgG, IgA and IgM levels were examined in children treated for different malignant tumors. Chemotherapy decreased IgG and mainly IgM. There was increased incidence of infectious complications in IgG deficiency.

• MeSH
• dítě MeSH
• imunoglobulin A krev   MeSH
• imunoglobulin G krev   MeSH
• imunoglobulin M krev   MeSH
• imunoglobuliny krev   MeSH
• infekce etiologie   imunologie   MeSH
• lidé MeSH
• nádory ledvin komplikace   farmakoterapie   imunologie   MeSH
• nádory měkkých tkání komplikace   farmakoterapie   imunologie   MeSH
• nádory komplikace   farmakoterapie   imunologie   MeSH
• následné studie MeSH
• nehodgkinský lymfom komplikace   farmakoterapie   imunologie   MeSH
• neuroblastom komplikace   farmakoterapie   imunologie   MeSH
• protinádorové látky terapeutické užití   MeSH
• rozdělení chí kvadrát MeSH
• sarkom komplikace   farmakoterapie   imunologie   MeSH
• Wilmsův nádor komplikace   farmakoterapie   imunologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• imunoglobulin A MeSH
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• imunoglobuliny MeSH
• protinádorové látky MeSH