• Keywords
• advanced heart failure, continuous flow pumps, left ventricular assist device, mechanical circulatory support,
• MeSH
• Time Factors MeSH
• Ventricular Function, Left * MeSH
• Risk Assessment MeSH
• Prosthesis Implantation adverse effects   instrumentation   mortality   standards   MeSH
• Cardiology standards   MeSH
• Clinical Decision-Making MeSH
• Consensus MeSH
• Humans MeSH
• Evidence-Based Medicine standards   MeSH
• Recovery of Function MeSH
• Heart-Assist Devices standards   MeSH
• Prosthesis Design standards   MeSH
• Risk Factors MeSH
• Waiting Lists * mortality   MeSH
• Heart Failure diagnosis   mortality   physiopathology   therapy   MeSH
• Lung Transplantation adverse effects   mortality   standards   MeSH
• Heart Transplantation adverse effects   mortality   standards   MeSH
• Patient Selection MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Practice Guideline MeSH

INTRODUCTION: Amanita phalloides poisoning is a potentially fatal cause of acute liver failure. The aim of this study was to analyze the impact of initial patients' characteristics and different treatment modalities on the outcome of patients with liver failure caused by Amanita poisoning. MATERIAL AND METHODS: We retrospectively evaluated 23 patients admitted to our center between July 2007 and August 2016. RESULTS: Mean time interval between Amanita phalloides ingestion and the onset of gastrointestinal symptoms was 12.48 ± 9.88 hours and the interval between ingestion and hospital admission 26.26 ± 15.14 hours. The treatment was intiated by oral decontamination using activated charcoal followed by intravenous rehydration and high doses of intravenous N-acetylcysteine and silibinin. Fourteen patients (61%) underwent extracorporeal elimination method. Ten patients had plasmapheresis, 1 patient had hemoperfusion, and 5 patients had fractionated plasma separation and adsorption. Seven patients who met King's College Criteria were listed for urgent liver transplantation; one of them died before transplantation. Six patients underwent liver transplantation; the mean waiting time was 6.5 ± 12.0 days (range, 1-31 days). One patient died 2 months afterward. All 16 patients who did not meet King's College Criteria and received conservative treatment survived. CONCLUSION: Our results documented a good prognostic value of standard King's College Criteria for indication of urgent liver transplantation in acute liver failure caused by Amanita phalloides poisoning. Fractionated plasma separation and adsorption may contribute to low mortality on the waiting list. Intensive care and extracorporeal elimination methods seem to be crucial points of the conservative treatment.

• MeSH
• Acetylcysteine administration & dosage   MeSH
• Liver Failure, Acute etiology   therapy   MeSH
• Amanita MeSH
• Antidotes administration & dosage   MeSH
• Antioxidants administration & dosage   MeSH
• Renal Dialysis methods   MeSH
• Adult MeSH
• Charcoal administration & dosage   MeSH
• Hemoperfusion methods   MeSH
• Conservative Treatment methods   MeSH
• Middle Aged MeSH
• Humans MeSH
• Mushroom Poisoning complications   therapy   MeSH
• Critical Care methods   MeSH
• Plasmapheresis methods   MeSH
• Prognosis MeSH
• Retrospective Studies MeSH
• Waiting Lists mortality   MeSH
• Silybin MeSH
• Silymarin administration & dosage   MeSH
• Severity of Illness Index * MeSH
• Fluid Therapy methods   MeSH
• Liver Transplantation methods   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Evaluation Study MeSH
• Names of Substances
• Acetylcysteine MeSH
• Antidotes MeSH
• Antioxidants MeSH
• Charcoal MeSH
• Silybin MeSH
• Silymarin MeSH

BACKGROUND: Lung transplantation is a well established treatment for advanced lung diseases. METHODS: We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation. RESULTS: Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list. The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%. The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively. CONCLUSION: The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature. We confirmed a less favorable prognosis of BCC-colonized patients.

• MeSH
• Burkholderia cepacia complex isolation & purification   MeSH
• Time Factors MeSH
• Cystic Fibrosis microbiology   mortality   surgery   MeSH
• Child MeSH
• Adult MeSH
• Risk Assessment MeSH
• Burkholderia Infections microbiology   MeSH
• Kaplan-Meier Estimate MeSH
• Humans MeSH
• Survival Rate MeSH
• Adolescent MeSH
• Young Adult MeSH
• Risk Factors MeSH
• Waiting Lists * mortality   MeSH
• Lung Transplantation * adverse effects   mortality   MeSH
• Treatment Outcome MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH
• Geographicals
• Czech Republic MeSH