AIMS: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. METHODS: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. RESULTS: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. CONCLUSIONS: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.

• Klíčová slova
• Comorbidity, Diabetes mellitus, Diabetic foot ulcer, Health-related quality of life, Longitudinal study,
• MeSH
• činnosti denního života * MeSH
• deprese epidemiologie   MeSH
• diabetická noha epidemiologie   psychologie   terapie   MeSH
• hojení ran MeSH
• kohortové studie MeSH
• kombinovaná terapie škodlivé účinky   MeSH
• komorbidita MeSH
• komplikace diabetu epidemiologie   psychologie   terapie   MeSH
• kvalita života * MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• osobní újma zaviněná nemocí * MeSH
• prospektivní studie MeSH
• psychiatrické posuzovací škály MeSH
• self-management MeSH
• senioři MeSH
• úzkost epidemiologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH

• MeSH
• adaptace psychologická * MeSH
• činnosti denního života psychologie   MeSH
• deprese komplikace   MeSH
• diabetická noha psychologie   MeSH
• kvalita života psychologie   MeSH
• lidé MeSH
• osobní újma zaviněná nemocí * MeSH
• psychický stres komplikace   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• komentáře MeSH

UNLABELLED: The aim of our case-control study was to compare selected psychological and social characteristics between diabetic patients with and without the DF (controls). METHODS: 104 patients with and 48 without DF were included into our study. Both study groups were compared in terms of selected psychosocial characteristics. RESULTS: Compared to controls, patients with DF had a significantly worse quality of life in the area of health and standard of living as shown by lower physical health domain (12.7 ± 2.8 versus 14.7 ± 2.5; P < 0.001) and environment domain (14.1 ± 2.2 versus 15 ± 1.8; P < 0.01) that negatively correlated with diabetes duration (r = -0.061; P = 0.003). Patients with DF subjectively felt more depressed in contrast to controls (24.5 versus 7.3%; P < 0.05); however, the depressive tuning was objectively proven in higher percentage in both study groups (83.2 versus 89.6; NS). We observed a significantly lower level of achieved education (P < 0.01), more patients with disability pensions (P < 0.01), and low self-support (P < 0.001) in patients with the DF compared to controls. In the subgroup of patients with a previous major amputation and DF (n = 6), there were significantly worse outcomes as in the environment domain (P < 0.01), employment status, and stress readaptation (P < 0.01) in contrast to the main study groups. CONCLUSIONS: Patients with DF had a predominantly worse standard of living. In contrast to our expectations, patients with DF appeared to have good stress tolerability and mental health (with the exception of patients with previous major amputation) and did not reveal severe forms of depression or any associated consequences.

• MeSH
• adaptace psychologická * MeSH
• amputace škodlivé účinky   ekonomika   psychologie   rehabilitace   MeSH
• činnosti denního života psychologie   MeSH
• deprese komplikace   ekonomika   epidemiologie   MeSH
• depresivní porucha unipolární komplikace   ekonomika   epidemiologie   MeSH
• diabetes mellitus ekonomika   patofyziologie   psychologie   MeSH
• diabetická noha komplikace   patofyziologie   psychologie   chirurgie   MeSH
• incidence MeSH
• kvalita života psychologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• neuritida komplikace   epidemiologie   MeSH
• osobní újma zaviněná nemocí * MeSH
• psychiatrické posuzovací škály MeSH
• psychický stres komplikace   ekonomika   epidemiologie   rehabilitace   MeSH
• senioři MeSH
• socioekonomické faktory MeSH
• studie případů a kontrol MeSH
• stupeň závažnosti nemoci MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH