This study presents an innovative multifunctional system in fabricating new functional wound dressing (FWD) products that could be used for skin regeneration, especially in cases of infected chronic wounds and ulcers. The innovation is based on the extraction, characterization, and application of collagen (CO)/chitosan-glucan complex hollow fibers (CSGC)/aloe vera (AV) as a novel FWS. For the first time, specific hollow fibers were extracted with controlled inner (500-900 nm)/outer (2-3 µm) diameters from mycelium of Schizophyllum commune. Further on, research and evaluation of morphology, hydrolytic stability, and swelling characteristics of CO/CSGC@AV were carried out. The obtained FWS showed high hydrolytic stability with enhanced swelling characteristics compared to native collagen. The hemostatic effect of FWS increased significantly in the presence of CSGC, compared to native CO and displayed excellent biocompatibility which was tested by using normal human dermal fibroblast (NHDF). The FWS showed high antibacterial activity against different types of bacteria (positive/negative grams). From in vivo measurements, the novel FWS increased the percentage of wound closure after one week of treatment. All these results imply that the new CO/CSGC@AV-FWD has the potential for clinical skin regeneration and applying for controlled drug release.

• Klíčová slova
• Bactericidal performance, Hemostasis, Hollow fibers, Multifunctional wound dressing,
• MeSH
• Aloe * chemie   MeSH
• antibakteriální látky chemie   izolace a purifikace   farmakologie   MeSH
• Bacteria účinky léků   růst a vývoj   MeSH
• chitosan chemie   izolace a purifikace   farmakologie   MeSH
• fibrilární kolageny chemie   izolace a purifikace   farmakologie   MeSH
• glukany chemie   izolace a purifikace   farmakologie   MeSH
• hojení ran účinky léků   MeSH
• kultivované buňky MeSH
• kůže účinky léků   zranění   patologie   MeSH
• lidé MeSH
• modely nemocí na zvířatech MeSH
• mycelium * chemie   MeSH
• obvazy * MeSH
• potkani Wistar MeSH
• rány a poranění farmakoterapie   patologie   MeSH
• rostlinné extrakty chemie   izolace a purifikace   farmakologie   MeSH
• Schizophyllum * chemie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• antibakteriální látky MeSH
• chitosan MeSH
• fibrilární kolageny MeSH
• glukany MeSH
• rostlinné extrakty MeSH