A total of 65 isolates representing 13 Emericella taxa (5 isolates of each of 12 species and 1 variety) had the ability to transform progesterone into 11 alpha-hydroxyprogesterone. A systematic variation could be observed between the different tested Emericella taxa with respect to the transformation products. The isolates were divided according to the transformation types into six groups: (1) progesterone was hydroxylated into 6 beta-hydroxyprogesterone, 11 alpha-hydroxyprogesterone and 6 beta,11 alpha-dihydroxyprogesterone--found in Emericella acristata and E. dentata; (2) E. aurantio-brunna and E. parvathecia hydroxylated progesterone into 11 alpha-hydroxyprogesterone, 17 alpha-hydroxyprogesterone and 11 alpha,17 alpha-dihydroxyprogesterone; (3) E. nidulans and E. quadrilineata formed the same three products as members of group (2) and form epicortisol; (4) E. nidulans var. lata, E. bicolor and E. variecolor transformed progesterone into a mixture of mono-, di- and trihydroxy products; (5) E. striata and E. sublata exhibited an oxidative splitting of the progesterone side chain in position C-17 and hydroxylated progesterone into mono- and dihydroxy products; (6) E. rugulosa and E. unguis had the ability to degrade progesterone side-chain and to hydroxylate it into mono-, di- and trihydroxy products. This biochemical differentiation may supplement the morphological and other biochemical criteria used in the classification of the Emericella taxa.

• MeSH
• Ascomycota klasifikace   růst a vývoj   metabolismus   MeSH
• chromatografie na tenké vrstvě MeSH
• hydroxyprogesterony metabolismus   MeSH
• kultivační média MeSH
• mykologické určovací techniky MeSH
• progesteron metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• 11-hydroxyprogesterone MeSH Prohlížeč
• hydroxyprogesterony MeSH
• kultivační média MeSH
• progesteron MeSH

The results of measurement of 17-hydroxyprogesterone (17-OH-P) in 125 samples of amniotic fluid (AF) from early amniocenteses are presented. The fetuses from all pregnancies studied were unaffected by congenital adrenal hyperphasia caused by 21-hydroxylase deficiency. The AF 17-OH-P level increases slightly but significantly between the 11th and 15th week of gestation, with a maximum in the 14th week. There is no difference between the values measured in male and female fetuses. The AF 17-OH-P levels from the early gestation were compared with those from the 16th-22nd week of pregnancy (published previously). The overall differences of AF 17-OH-P concentrations when considered in all gestational age groups in the whole period 12-22 weeks were statistically insignificant. Thus, the biochemical prenatal diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency and control of its early fetal treatment could be carried out starting from the end of the first trimester in the same way as at the later period of gestation.

• MeSH
• 17-alfa-hydroxyprogesteron MeSH
• druhý trimestr těhotenství metabolismus   MeSH
• gestační stáří MeSH
• hydroxyprogesterony metabolismus   MeSH
• interval spolehlivosti MeSH
• kongenitální adrenální hyperplazie diagnóza   MeSH
• lidé MeSH
• plodová voda metabolismus   MeSH
• prenatální diagnóza MeSH
• první trimestr těhotenství metabolismus   MeSH
• referenční hodnoty MeSH
• sexuální faktory MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• 17-alfa-hydroxyprogesteron MeSH
• hydroxyprogesterony MeSH

• MeSH
• antibiotická rezistence MeSH
• antifungální látky farmakologie   MeSH
• Arthrodermataceae účinky léků   růst a vývoj   metabolismus   MeSH
• biotransformace MeSH
• chemické jevy MeSH
• chemie MeSH
• chromatografie na tenké vrstvě MeSH
• druhová specificita MeSH
• hydroxylace MeSH
• hydroxyprogesterony metabolismus   farmakologie   MeSH
• indikátory a reagencie MeSH
• kultivační média MeSH
• papírová chromatografie MeSH
• progesteron metabolismus   farmakologie   MeSH
• steroly metabolismus   farmakologie   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antifungální látky MeSH
• hydroxyprogesterony MeSH
• indikátory a reagencie MeSH
• kultivační média MeSH
• progesteron MeSH
• steroly MeSH