Sexual dysfunctions in men are complex disorders that consist of organic and psychogenic components. The most common sexual dysfunction is erectile dysfunction. It is the inability to achieve or maintain an erection for satisfactory sexual performance. This disorder can be caused by high blood pressure, heart disease, vascular problems, psychological and hormonal factors such as problems with testosterone and prolactin levels. In this study, we tested the relationship between erectile dysfunction, hyperprolactinemia and psychosocial stress. Clinical examinations of 60 patients with erectile dysfunction, which also included psychosocial stress, focussed on patient history, comprehensive sexological examination, biochemical analyses of serum prolactin, total testosterone and thyroid-stimulating hormone with psychometric evaluation of erectile function and a checklist of trauma symptoms (TSC-40). The results show significant Spearman correlations of psychometric evaluation of erectile function with prolactin (R = .50) and results of the trauma checklist score (R = .55) and significant Spearman correlations between TSC-40 and prolactin (R = .52). This result indicates a significant relationship between erectile dysfunction, hyperprolactinemia and stress symptoms in men.
- Klíčová slova
- erectile dysfunction, hyperprolactinemia, international index of erectile function questionnaire, psychosocial stress,
- MeSH
- erekce penisu MeSH
- erektilní dysfunkce * etiologie MeSH
- hyperprolaktinemie * komplikace MeSH
- lidé MeSH
- prolaktin MeSH
- psychický stres komplikace MeSH
- testosteron MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- prolaktin MeSH
- testosteron MeSH
Plasma prolactin was measured in genetically hypertensive obese Koletsky rats, in their lean siblings and in normotensive rats of Wistar strain. Lean as well as obese females show hyperprolactinemia. The males of Wistar strain as well as obese rats and their siblings show comparable prolactinemia except lean males which show higher level than Wistar males. Sex dependence of prolactinemia is missing in the rats of Wistar strain. Long lasting terguride treatment decreases prolactinemia in obese as well as lean rats of both sexes. The drug showed decreased prolactinemia in the males of Wistar strain. When the group of rats are considered in correlation computation positive correlation can be documented between total plasma cholesterol and plasma prolactin. In obese females positive correlation was found between plasma insulin and plasma prolactin.
- MeSH
- agonisté dopaminu farmakologie MeSH
- hyperprolaktinemie komplikace MeSH
- hypertenze krev MeSH
- inzulin krev MeSH
- krysa rodu Rattus MeSH
- lipidy krev MeSH
- lisurid analogy a deriváty farmakologie MeSH
- obezita krev komplikace MeSH
- potkani inbrední SHR MeSH
- potkani Wistar MeSH
- prolaktin krev MeSH
- tělesná hmotnost MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- agonisté dopaminu MeSH
- dironyl MeSH Prohlížeč
- inzulin MeSH
- lipidy MeSH
- lisurid MeSH
- prolaktin MeSH
- MeSH
- hyperprolaktinemie komplikace MeSH
- lidé MeSH
- těhotenství MeSH
- ženská infertilita etiologie MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The usage of metergoline in patients with infertility and different forms (hinds) of hyperprolactinaemia was studied for 90 days at a dose of 12 mg. It gives a possibility to stimulate ovulation in 64% of patients and gain pregnancy in 8% of patients. In order to exceed the percentage of inpregnantion the course of medicine can be enlarged up to 6 months.
- MeSH
- hyperprolaktinemie komplikace farmakoterapie MeSH
- lidé MeSH
- metergolin terapeutické užití MeSH
- těhotenství MeSH
- ženská infertilita farmakoterapie etiologie MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- metergolin MeSH
The purpose of the study was to describe hypothalamopituitary functional status of females with infertility in combination with hyperprolactinemia. To this end, changes in prolactin, LH, FSH and TSH in response to the administration of releasing hormones (Gn--RH and TRH) and the dopamine antagonist metoclopramide were assessed in 28 patients with hyperprolactinemic amenorrhea and 5 normal cycling women. Lactotrophs were found to be resistant to functional tests, the resistance increasing as the prolactin level went up. Gonadotrophic and thyrotrophic response to functional tests, on the contrary, increased with the progress of hyperprolactinemia. A conclusion is drawn that stable hyperprolactinemia is a result of disturbance in lactotrophic receptor apparatus, for which reason lactotrophs are no longer sensitive to dophamine inhibiting effect on prolactin secretion.
- MeSH
- dospělí MeSH
- hyperprolaktinemie krev komplikace patofyziologie MeSH
- hypofyzární hormony krev MeSH
- lidé MeSH
- systém hypotalamus-hypofýza patofyziologie MeSH
- těhotenství MeSH
- ženská infertilita krev etiologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- hypofyzární hormony MeSH
28 women with hyperprolactinaemia were examined (prolactin levels varied from 720 to 66000mlU/l). These patients were subjected to the functional tests with GnRH, TRH and metoclopramid. In all groups of the patients, who were devided acording Prolactin levels, the sensitivity of lactotrophs was decreased. There is reserve correlation between levels of the prolactin and gonadotrophins (r = -0.64). The test with metoclopromid is more informative in the diagnosis of tumoral and functional hyperprolactinaemia.
- MeSH
- dospělí MeSH
- gonadotropiny hypofyzární krev MeSH
- hyperprolaktinemie krev komplikace diagnóza MeSH
- lidé MeSH
- testy funkce hypofýzy * MeSH
- ženská infertilita etiologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- gonadotropiny hypofyzární MeSH
- MeSH
- corpus luteum patofyziologie MeSH
- dospělí MeSH
- ergoliny terapeutické užití MeSH
- hyperprolaktinemie komplikace MeSH
- lidé MeSH
- lisurid analogy a deriváty terapeutické užití MeSH
- menstruační poruchy farmakoterapie etiologie MeSH
- mladiství MeSH
- ženská infertilita farmakoterapie etiologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dironyl MeSH Prohlížeč
- ergoliny MeSH
- lisurid MeSH
- MeSH
- bromokriptin aplikace a dávkování terapeutické užití MeSH
- dospělí MeSH
- hyperprolaktinemie komplikace farmakoterapie MeSH
- lidé MeSH
- těhotenství MeSH
- ženská infertilita etiologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- bromokriptin MeSH
- MeSH
- dialýza ledvin škodlivé účinky psychologie MeSH
- dospělí MeSH
- hyperprolaktinemie komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- menstruační poruchy krev etiologie psychologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
