It has recently been proposed that heart failure is a risk factor for Alzheimer's disease. Decreased cerebral blood flow and neurohormonal activation due to heart failure may contribute to the dysfunction of the neurovascular unit and cause an energy crisis in neurons. This leads to the impaired clearance of amyloid beta and hyperphosphorylation of tau protein, resulting in the formation of amyloid beta plaques and neurofibrillary tangles. In this article, we will summarize the current understanding of the relationship between heart failure and Alzheimer's disease based on epidemiological studies, brain imaging research, pathological findings and the use of animal models. The importance of atherosclerosis, myocardial infarction, atrial fibrillation, blood pressure and valve disease as well as the effect of relevant medications will be discussed.

• Klíčová slova
• Alzheimer′s disease, dementia, heart failure, neurocardiology, neurovascular unit,
• MeSH
• Alzheimerova nemoc epidemiologie   MeSH
• fibrilace síní epidemiologie   MeSH
• hypertenze patofyziologie   MeSH
• infarkt myokardu epidemiologie   MeSH
• intrakraniální arterioskleróza epidemiologie   MeSH
• lidé MeSH
• modely nemocí na zvířatech MeSH
• mozkový krevní oběh MeSH
• rizikové faktory MeSH
• srdeční selhání epidemiologie   patofyziologie   MeSH
• syndromy spánkové apnoe epidemiologie   MeSH
• tepový objem MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH