OBJECTIVES: The changes in the serum levels of lipopolysaccharide binding protein (LBP) and sCD14 during cardiac surgery were followed in this study. DESIGN: Thirty-four patients, 17 in each group, were randomly assigned to coronary artery bypass grafting surgery performed either with ("on-pump") or without ("off-pump") cardiopulmonary bypass. LBP and sCD14 were evaluated by ELISA. RESULTS: The serum levels of LBP were gradually increased from the 1st postoperative day and reached their maximum on the 3rd postoperative day in both "on-pump" and "off-pump" patients (30.33+/-9.96 microg/mL; 37.99+/-16.58 microg/mL), respectively. There were no significant differences between "on-pump" and "off-pump" patients regarding LBP. The significantly increased levels of sCD14 from the 1st up to the 7th postoperative day in both "on-pump" and "off-pump" patients were found with no significant differences between these groups. No correlations between LBP and sCD14 and IL-6, CRP and long pentraxin PTX3 levels were found. CONCLUSIONS: The levels of LBP and sCD14 are elevated in cardiac surgical patients being similar in both groups. These molecules are not produced as acute phase proteins in these patients.

• MeSH
• antigeny CD14 krev   chemie   MeSH
• biologické modely MeSH
• C-reaktivní protein metabolismus   MeSH
• časové faktory MeSH
• ELISA MeSH
• interleukin-6 metabolismus   MeSH
• kardiopulmonální bypass škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• membránové glykoproteiny metabolismus   MeSH
• proteiny akutní fáze metabolismus   MeSH
• senioři MeSH
• sérový amyloidový protein metabolismus   MeSH
• statistické modely MeSH
• transportní proteiny metabolismus   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• antigeny CD14 MeSH
• C-reaktivní protein MeSH
• interleukin-6 MeSH
• lipopolysaccharide-binding protein MeSH Prohlížeč
• membránové glykoproteiny MeSH
• proteiny akutní fáze MeSH
• PTX3 protein MeSH Prohlížeč
• sérový amyloidový protein MeSH
• transportní proteiny MeSH