The antibacterial effects of essential oils and their components (EOCs) are usually attributed to effects on membranes and metabolism. Studies of the effects of EOCs on protein expression have primarily analysed proteins larger than 10 kDa using gel electrophoresis. In the present study, we used MALDI-TOF-MS to investigate the effects of EOCs on low-molecular-weight proteins. From 297 m/z features, we identified 94 proteins with important differences in expression among untreated samples, samples treated with EOCs, and samples treated with antibiotics, peroxide, or chlorine. The targets of these treatments obviously differ, even among EOCs. In addition to ribosomal proteins, stress-, membrane- and biofilm-related proteins were affected. These findings may provide a basis for identifying new targets of essential oils and synergies with other antibiotics.

• MeSH
• antibakteriální látky metabolismus   MeSH
• Escherichia coli účinky léků   fyziologie   MeSH
• fyziologický stres * MeSH
• molekulová hmotnost MeSH
• oleje prchavé metabolismus   MeSH
• proteiny z Escherichia coli analýza   chemie   MeSH
• proteom analýza   MeSH
• spektrometrie hmotnostní - ionizace laserem za účasti matrice * MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antibakteriální látky MeSH
• oleje prchavé MeSH
• proteiny z Escherichia coli MeSH
• proteom MeSH