The assessment and monitoring of the tissue perfusion is extremely important in critical conditions involving circulatory shock. There is a wide range of established methods for the assessment of cardiac output as a surrogate of oxygen delivery to the peripheral tissues. However, the evaluation of whether particular oxygen delivery is sufficient to ensure cellular metabolic demands is more challenging. In recent years, specific biochemical parameters have been described to indicate the status between tissue oxygen demands and supply. In this review, the authors summarize the application of some of these biochemical markers, including mixed venous oxygen saturation (SvO2), lactate, central venous-arterial carbon dioxide difference (PCO2 gap), and PCO2 gap/central arterial-to-venous oxygen difference (Ca-vO2) for hemodynamic assessment of tissue perfusion. The thorough monitoring of the adequacy of tissue perfusion and oxygen supply in critical conditions is essential for the selection of the most appropriate therapeutic strategy and it is associated with improved clinical outcomes.

• Klíčová slova
• Circulatory shock, Hemodynamic monitoring, Lactate, Microcirculation, Oxygen saturation, Tissue perfusion,
• MeSH
• arterie metabolismus   MeSH
• biologické markery metabolismus   MeSH
• blízká infračervená spektroskopie MeSH
• glukosa metabolismus   MeSH
• hemodynamika MeSH
• hypoxie MeSH
• kyselina mléčná MeSH
• kyslík metabolismus   MeSH
• lidé MeSH
• mikrocirkulace * MeSH
• monitorování fyziologických funkcí metody   MeSH
• oxid uhličitý MeSH
• perfuze MeSH
• prognóza MeSH
• spotřeba kyslíku MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• biologické markery MeSH
• glukosa MeSH
• kyselina mléčná MeSH
• kyslík MeSH
• oxid uhličitý MeSH