• MeSH
• amidinotransferasy metabolismus   MeSH
• antibakteriální látky metabolismus   MeSH
• Bacillus metabolismus   MeSH
• Bacteria metabolismus   MeSH
• buněčná stěna metabolismus   MeSH
• neomycin metabolismus   MeSH
• Penicillium metabolismus   MeSH
• Streptomyces griseus metabolismus   MeSH
• streptomycin metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• amidinotransferasy MeSH
• antibakteriální látky MeSH
• neomycin MeSH
• streptomycin MeSH

Strains of Streptomyces coeruleorubidus ISP 5145, JA 10092 and 39-146, differing mutually in antibiotic activity, were found to produce identical spectrum of metabolites (at least nine antibiotically active glycosides, 13-dihydrodaunomycinone, epsilon-rhodomycinone and a larger number of unidentified compounds); only trace quantities of daunomycin and daunomycinone could be detected. A fraction of glycosides with a higher RF (0.4-0.7), isolated from strain 39-146, could be transformed to daunomycin by mild hydrolysis and to daunomycinone by total hydrolysis. Streptomyces peucetius IMI 101 335 differed from Streptomyces coeruleorubidus in an increased production of epsilon-rhodomycinone and a lower content of glycosides; the zone of daunomycin was most pronounced among the glycoside spots. Streptomyces coeruleorubidus 39-146 exhibited the highest activity in a medium containing 3.5% soluble starch, 3.0% soybean meal, 0.3% NaCl and 0.3% CaCo3; glucose was a more useful carbon source for the remaining strains. The activity of Streptomyces coeruleoribidus was inhibited by 1-propanol, Na-propionate, 5,5-diethylbarbiturate and bacitracin. Ferrous sulphate stimulated the production of glycosides only in strain JA 10092, decreasing simultaneously the production of aglycones.

• MeSH
• chromatografie na tenké vrstvě MeSH
• daunomycin analogy a deriváty   biosyntéza   izolace a purifikace   MeSH
• fermentace MeSH
• glykosidy biosyntéza   MeSH
• kultivační média MeSH
• ponoření MeSH
• Streptomyces metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• daunomycin MeSH
• glykosidy MeSH
• kultivační média MeSH