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Nejvíce citované: 12505793

1 citací v PubMed Filtry

Nejvíce citovaný článek - PubMed ID 12505793

Záznam nenalezen v Medvik. Navštivte PubMed 12505793

Článek

Analysis of shared heritability in common disorders of the brain

Brainstorm Consortium
Autor Brainstorm Consortium
Anttila, Verneri
Autor Anttila, Verneri ORCID Analytic Translational Genetics Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA. verneri.anttila@gmail.com acorvin@tcd.ie bneale@broadinstitute.org Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Bulik-Sullivan, Brendan
Autor Bulik-Sullivan, Brendan Analytic Translational Genetics Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Finucane, Hilary K
Autor Finucane, Hilary K ORCID Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Walters, Raymond K
Autor Walters, Raymond K ORCID Analytic Translational Genetics Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Bras, Jose
Autor Bras, Jose UK Dementia Research Institute, University College London, London, UK Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK
Duncan, Laramie
Autor Duncan, Laramie ORCID Analytic Translational Genetics Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California, USA
Escott-Price, Valentina
Autor Escott-Price, Valentina ORCID Cardiff University, Medical Research Council Center for Neuropsychiatric Genetics & Genomics, Institute of Psychology, Medicine & Clinical Neuroscience, Cardiff, UK Dementia Research Institute, Cardiff University, Cardiff, UK
Falcone, Guido J
Autor Falcone, Guido J ORCID Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Gormley, Padhraig
Autor Gormley, Padhraig ORCID Analytic Translational Genetics Unit, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

Science (New York, N.Y.). 2018 Jun 22 ; 360 (6395) : .

Science
ISSN 1095-9203 | 0036-8075
Zdroj

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

MeSH
celogenomová asociační studie MeSH
duševní poruchy klasifikace diagnóza genetika MeSH
fenotyp MeSH
genetická variace MeSH
kvantitativní znak dědičný MeSH
lidé MeSH
nemoci mozku klasifikace diagnóza genetika MeSH
rizikové faktory MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Research Support, N.I.H., Extramural MeSH

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