JavaScript is NOT enabled !

Please enable JavaScript.

* Show help

Reset

Most cited: 13876303

6 citations in PubMed Filters

Most cited article - PubMed ID 13876303

Microbial transformation of steroids. XVII. Transformation of progesterone by various species and strains of Penicillium

Folia microbiologica. 1962 Mar ; 7 () : 121-5.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Article

Progesterone side-chain degradation by some species of Aspergillus flavus group

Folia microbiologica. 2000 ; 45 (3) : 243-7.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Seventy isolates belonging to 6 species and one variety of A. flavus group were shown to degrade the progesterone side-chain to yield delta 4-androstene-3,17-dione and testosterone. The isolates of five species (A. flavo-furcatis, A. flavus, A. oryzae, A. parasiticus and A. tamarii) possessed enzyme systems catalyzing the opening of ring D and formed testololactone as final steroid metabolite in addition to their ability to produce the above mentioned two products. 11 beta-Hydroxy-delta 4-androstene-3,17-dione was formed by only A. flavus and A. tamarii while 11 beta-hydroxytestosterone was produced by A. flavo-furcatis, A. parasiticus and A. subolivaceus. The chromatographic resolution of the mixture products obtained (when the selective isolate of each species reacted with 1 g of progesterone) revealed that 60-75% of progesterone was converted into delta 4-androstene-3,17-dione (8-30%), testosterone (7-33%), testololactone (14-37%) and other products (3-40%). The most bioconversion activity was exhibited by A. oryzae, followed by A. parasiticus. The highest values of delta 4-androstene-3,17-dione (30% of added progesterone) and testosterone (33%) were formed by A. flavus var. columnaris while those of testololactone (37%) were produced by A. oryzae. A systematic variation could be observed between the different tested species of A. flavus group with respect to the transformation reactions of progesterone. Comparative biotransformation results showed that essential differences exist between the tested species in this group; this biochemical differentiation may supplement the morphological and other physiological criteria used in the identification of the different species in the A. flavus group.

MeSH
Androstenes metabolism MeSH
Aspergillus flavus classification growth & development metabolism MeSH
Mycological Typing Techniques MeSH
Progesterone chemistry metabolism MeSH
Spectrophotometry, Infrared MeSH
Testolactone metabolism MeSH
Testosterone metabolism MeSH
Chromatography, High Pressure Liquid MeSH
Publication type
Journal Article MeSH
Names of Substances
Androstenes MeSH
Progesterone MeSH
Testolactone MeSH
Testosterone MeSH

Article

Steroid transformations as a biochemical feature of the genus Paecilomyces

Folia microbiologica. 1976 ; 21 (1) : 70-2.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Article

Steroid derivatives. LXXIX. Microbial 15 beta-hydroxylation of 17 alpha-acetoxy-16-methylene derivatives of the pregnane series by the action of Cunninghamella blakesleeana

Folia microbiologica. 1976 ; 21 (2) : 144-51.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Hydroxylation of 17 alpha-acetoxy-6-chloro-16-methylene-4,6-pregnadiene-3,20-dione (Chlorosuperlutin, I) by Cunninghamella blakesleeana yielded a 15 beta-hydroxyderivative II. Analogous transformation of 17 alpha-acetoxy-16-methylene-4,6-pregnadiene-3,20-dione (Superlutin, IV) included a hydroxylation in position 15 beta and probably also in 11 beta with a concomitant reduction of the 6,7-double bond.