Nejvíce citovaný článek - PubMed ID 15748033
Vliv perorálního osídlení probiotickým kmenem E.coli po narození na výskyt opakovaných infekcí, alergií a vývoj nekterých imunologických ukazatelů. Výsledky dlouhodobého sledování
[Influence of oral colonization with probiotic E. coli strain after birth on frequency of recurrent infections, allergy and development of some immunologic parameters. Long-term studies]
Influence of intestinal colonization by a probiotic E. coli strain on the incidence of bacterial pathogens in stool and allergic symptoms during the 1st year of life was monitored in 3 groups: colonized children of allergic mothers (AC; n = 52), noncolonized children of allergic mothers (AN; n = 50), children of nonallergic mothers (NC; n = 42). Colinfant vaccine was administered within 2 d after birth, 3 x a week over a period of 4 weeks. Stool samples were examined after 2 d and at the age of 3, 6 and 12 months. At 3 months E. coli was present in 90 %, at 12 months in 73 % of AC. Pathogens were significantly less frequent on day 3 and at 3 months in AC vs. AN (15 vs. 61 %, p < 0.001; 15 vs. 38 %, p < 0.01) and vs. NC (15 vs. 63 %, p < 0.001; 15 vs. 53 %, p < 0.001). AC exhibited lower incidence of Staphylococcus epidermidis than AN on day 3 (6 vs. 31 %, p < 0.001) and of Klebsiella strains on day 3 and at 3 months (4 vs. 20 %, p < 0.05; 5 vs. 24 %, p < 0.01). AC showed a lower incidence of Pseudomonas aeruginosa than NC on day 3 (6 vs. 31 %, p < 0.01) and Klebsiella spp. on day 3 and at 3 months (4 vs. 22 %, p < 0.05; 5 vs. 45 %, p < 0.001). No significant differences were recorded after 6 and 12 months. The incidence of allergies was 3 % in AC, 26 % in AN (p < 0.01), and 10 % in NC.
- MeSH
- alergie etiologie prevence a kontrola MeSH
- aplikace orální MeSH
- bakteriální infekce komplikace mikrobiologie prevence a kontrola MeSH
- Escherichia coli * MeSH
- incidence MeSH
- Klebsiella izolace a purifikace MeSH
- kojenec MeSH
- lidé MeSH
- následné studie MeSH
- nemoci střev komplikace mikrobiologie prevence a kontrola MeSH
- novorozenec MeSH
- přenašečství MeSH
- probiotika aplikace a dávkování MeSH
- Pseudomonas aeruginosa izolace a purifikace MeSH
- Staphylococcus epidermidis izolace a purifikace MeSH
- střeva mikrobiologie MeSH
- zdravotnické přehledy * MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
