The time course of production of odorous compounds, i.e. geosmin and oxolones, and of avermectins was determined during the cultivation of S. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3-5, the sum of oxolones being 60 microg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.

• MeSH
• Biotechnology methods   MeSH
• Fermentation MeSH
• Ivermectin analogs & derivatives   metabolism   MeSH
• Kinetics MeSH
• Naphthols metabolism   MeSH
• Odorants analysis   MeSH
• Gas Chromatography-Mass Spectrometry MeSH
• Streptomyces growth & development   metabolism   MeSH
• Volatilization MeSH
• Publication type
• Journal Article MeSH
• Evaluation Study MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• avermectin MeSH Browser
• geosmin MeSH Browser
• Ivermectin MeSH
• Naphthols MeSH