The time course of production of odorous compounds, i.e. geosmin and oxolones, and of avermectins was determined during the cultivation of S. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3-5, the sum of oxolones being 60 microg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.

• MeSH
• biotechnologie metody   MeSH
• fermentace MeSH
• ivermektin analogy a deriváty   metabolismus   MeSH
• kinetika MeSH
• naftoly metabolismus   MeSH
• odoranty analýza   MeSH
• plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
• Streptomyces růst a vývoj   metabolismus   MeSH
• volatilizace MeSH
• Publikační typ
• časopisecké články MeSH
• hodnotící studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• avermectin MeSH Prohlížeč
• geosmin MeSH Prohlížeč
• ivermektin MeSH
• naftoly MeSH