Nejvíce citovaný článek - PubMed ID 1821868
Macrotetrolide antibiotics produced by Streptomyces globisporus
A total of 307 new compounds, natural, semisynthetic or synthetic, were isolated at the Institute of microbiology during the last twelve years. Due to the development of separation (chromatographic) methods and of analytical methods used to determine the chemical structure of these compounds, i.e. NMR, MS and X-ray diffraction, many new metabolites could be described.
- MeSH
- biologické faktory chemie izolace a purifikace MeSH
- cyklické peptidy chemie izolace a purifikace MeSH
- enzymy chemie izolace a purifikace MeSH
- molekulární sekvence - údaje MeSH
- námelové alkaloidy chemie izolace a purifikace MeSH
- sacharidové sekvence MeSH
- sacharidy chemie izolace a purifikace MeSH
- sekvence aminokyselin MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- biologické faktory MeSH
- cyklické peptidy MeSH
- enzymy MeSH
- námelové alkaloidy MeSH
- sacharidy MeSH
Published results as well as patent applications on biological effects of macrotetrolides and nonactic acids are reviewed. Their antimicrobial, antiprotozoan (coccidiostatic), antiparasitic (anthelminthic), insecticidal and acaricidal (miticidal) effects and also newly described immunosuppressive and plant growth stimulating activities are described. Both theoretical papers and practical applications including the effects of macrotetrolides on the environment are included; a particular target organism and precise dosage (e.g. LD50) are reported, in agreement with the original papers. It appears that macrotetrolides and their homologs are very prospective bioactive compounds that find application in agriculture, forestry, human and veterinary medicine while their negative effects on the environment are restricted to a minimum (biological quality of soil and water etc.).
- MeSH
- anthelmintika farmakologie MeSH
- antibakteriální látky farmakologie MeSH
- antifungální látky farmakologie MeSH
- antiprotozoální látky farmakologie MeSH
- imunosupresiva farmakologie MeSH
- insekticidy farmakologie MeSH
- makrolidy MeSH
- mitochondrie účinky léků ultrastruktura MeSH
- roztoči účinky léků ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- anthelmintika MeSH
- antibakteriální látky MeSH
- antifungální látky MeSH
- antiprotozoální látky MeSH
- imunosupresiva MeSH
- insekticidy MeSH
- makrolidy MeSH
Thermosensitive submerged endospores formed by Streptomyces globisporus 0234 and its natural variant A resembled those of thermoresistant actinomycetes not only in their morphology ultrastructure, but also in the content of dipicolinic acid. The production of endospores containing this substance is unusual in Streptomyces while other features of the strain indicate relatedness to other streptomycetes. Chemotaxonomic analysis of variant A revealed the cell wall to be of chemotype I and fatty acid content typical of Streptomyces. Most characteristics of surface cultures of variant A coincided with those of the original strain 0234 and its endosporeless variant B. Both the strain 0234 and its variants A and B produced identical antibiotics and pesticidal compounds.
