Diseases of the central nervous system (CNS) mean for the human organism a potentially dangerous situation. An investigation of cerebrospinal fluid (CSF) provides important information about a character of CNS impairment in the decision-making diagnostic and therapeutic algorithm. The authors present a brief overview of available cerebrospinal fluid assays, shortened indication criteria, a recommended algorithm of CSF assessment in different suspected diseases, and a view of the external quality system. The whole portfolio of obtainable CSF methodology is further subdivided according to the adequate choice into the first and inevitable basic routine panel, and following complicated analyses of highly specialized character. The basic panel is considered for standard laboratories, the complete specialized assessment should be provided by a super-consulting laboratory.

• MeSH
• algoritmy MeSH
• cytologické techniky MeSH
• klinické laboratorní techniky MeSH
• lidé MeSH
• makrofágy MeSH
• mozkomíšní mok chemie   cytologie   MeSH
• proteiny v mozkomíšním moku analýza   MeSH
• směrnice pro lékařskou praxi jako téma * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• proteiny v mozkomíšním moku MeSH

A very rare clinical entity, so-called eosinophilic meningitis, classified by prevalence of eosinophils in cerebrospinal fluid (CSF), with the presence of pleiocytosis, has been recorded in our laboratory four times only in the last 24 years. A low glucose level, elevation of total protein and lactic acid in CSF were detected in all the clinical cases. The last two cases were made possible by using flow cytometry method; surprisingly, the presence was found in mature T-cells in CSF, predominantly helpers (CD3+, CD4+) and, practically, none is B-cells (CD19+), plasma cells (CD138+) and NK-cells.

• MeSH
• eozinofily imunologie   MeSH
• glukosa mozkomíšní mok   MeSH
• krevní proteiny mozkomíšní mok   MeSH
• kyselina mléčná mozkomíšní mok   MeSH
• lidé MeSH
• meningitida mozkomíšní mok   diagnóza   imunologie   MeSH
• počet leukocytů MeSH
• průtoková cytometrie MeSH
• T-lymfocyty pomocné-indukující imunologie   MeSH
• T-lymfocyty imunologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• glukosa MeSH
• krevní proteiny MeSH
• kyselina mléčná MeSH