OBJECTIVE: The need of today's research is to develop successful and reliable diabetic animal models for understanding the disease susceptibility and pathogenesis. Enormous success of animal models had already been acclaimed for identifying key genetic and environmental factors like Idd loci and effects of microorganisms including the gut microbiota. Furthermore, animal models had also helped in identifying many therapeutic targets and strategies for immune-intervention. In spite of a quite success, we have acknowledged that many of the discovered immunotherapies are working on animals and did not have a significant impact on human. Number of animal models were developed in the past to accelerate drug discovery pipeline. However, due to poor initial screening and assessment on inequivalent animal models, the percentage of drug candidates who succeeded during clinical trials was very low. Therefore, it is essential to bridge this gap between pre-clinical research and clinical trial by validating the existing animal models for consistency. RESULTS AND CONCLUSION: In this review, we have discussed and evaluated the significance of animal models on behalf of published data on PUBMED. Amongst the most popular diabetic animal models, we have selected six animal models (e.g. BioBreeding rat, "LEW IDDM rat", "Nonobese Diabetic (NOD) mouse", "STZ RAT", "LEPR Mouse" and "Zucker Diabetic Fatty (ZDF) rat" and ranked them as per their published literature on PUBMED. Moreover, the vision and brief imagination for developing an advanced and robust diabetic model of 21st century was discussed with the theme of one miceone human concept including organs-on-chips.

• Keywords
• Animal model, diabetes mellitus, humanized animal model, immunotherapies, meta-analysis, pathogens.,
• MeSH
• Diabetes Mellitus, Type 2 chemically induced   drug therapy   genetics   MeSH
• Species Specificity MeSH
• Diabetes Mellitus, Experimental chemically induced   drug therapy   MeSH
• Hypoglycemic Agents pharmacology   MeSH
• Humans MeSH
• Mice, Mutant Strains MeSH
• Mice, Inbred C57BL MeSH
• Mice, Inbred NOD MeSH
• Rats, Inbred BB MeSH
• Rats, Inbred Lew MeSH
• Rats, Zucker MeSH
• Forecasting MeSH
• Drug Evaluation, Preclinical trends   MeSH
• Streptozocin MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Hypoglycemic Agents MeSH
• Streptozocin MeSH