The diethyl ether extracts isolated from unfermented milk and milk fermented by Enterococcus faecium exhibited dose-dependent inhibition of mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), nitrovin (NIT), 5-nitro-2-furylacrylic acid (NFA) and UV-irradiation on the Ames bacterial test (Salmonella typhimurium strains TA97 and TA100) and the unicellular flagellate Euglena gracilis. Overall, the fermented milk extract was the most active against UV-irradiation, less active against NIT and MNNG, and the least active against NFA on bacteria. The highest antibleaching effects were observed against MNNG. The differences between antimutagenic effects from fermented and unfermented milk extracts were determined to be statistically significant at the 0.95 CI level.

• MeSH
• Acrylates toxicity   MeSH
• Antimutagenic Agents pharmacology   MeSH
• Enterococcus faecium metabolism   MeSH
• Euglena gracilis drug effects   MeSH
• Fermentation MeSH
• Methylnitronitrosoguanidine toxicity   MeSH
• Milk chemistry   metabolism   MeSH
• Mutagenesis * MeSH
• Nitrofurans toxicity   MeSH
• Nitrovin toxicity   MeSH
• Salmonella typhimurium drug effects   MeSH
• Ultraviolet Rays MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Acrylates MeSH
• Antimutagenic Agents MeSH
• Methylnitronitrosoguanidine MeSH
• Nitrofurans MeSH
• nitrofurylacrylic acid MeSH Browser
• Nitrovin MeSH

The mutagenic activity of more than 120 antimicrobial agents and protective components was investigated. Only Kathon showed a consistent increase in revertant counts in the Ames test on Salmonella typhimurium. The hereditary bleaching test on Euglena gracilis used for detecting extranuclear mutations, showed positive results for Kathon, triethanolamine and diamine silver tetraborate.

• MeSH
• Biological Assay methods   MeSH
• Borates adverse effects   pharmacology   MeSH
• Ethanolamines adverse effects   pharmacology   MeSH
• Euglena gracilis drug effects   genetics   MeSH
• Cosmetics adverse effects   pharmacology   MeSH
• Mutagenesis MeSH
• Salmonella typhimurium drug effects   MeSH
• Mutagenicity Tests methods   MeSH
• Thiazoles adverse effects   pharmacology   MeSH
• Hair Preparations adverse effects   pharmacology   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czechoslovakia MeSH
• Names of Substances
• Borates MeSH
• Ethanolamines MeSH
• Kathon 886 MeSH Browser
• Cosmetics MeSH
• tetraborate MeSH Browser
• Thiazoles MeSH
• triethanolamine MeSH Browser
• Hair Preparations MeSH