The topic of human circadian rhythms is not only attracting the attention of clinical researchers from various fields but also sparking a growing public interest. The circadian system comprises the central clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral clocks in various tissues that are interconnected; together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. Disruption of circadian regulation seems to be associated with metabolic disorders (particularly impaired glucose tolerance) and cardiovascular disease. Previous clinical trials revealed that disturbance of the circadian system, specifically due to shift work, is associated with an increased risk of type 2 diabetes mellitus. This review is intended to provide clinicians who wish to implement knowledge of circadian disruption in diagnosis and strategies to avoid cardio-metabolic disease with a general overview of this topic.

• Klíčová slova
• cardiovascular disease risk, circadian clock, circadian rhythm disruption, glucose tolerance, insulin sensitivity, time restricted eating, type 2 diabetes mellitus,
• MeSH
• chronobiologické poruchy patofyziologie   komplikace   MeSH
• cirkadiánní rytmus * fyziologie   MeSH
• diabetes mellitus 2. typu patofyziologie   metabolismus   MeSH
• kardiovaskulární nemoci * etiologie   patofyziologie   MeSH
• lidé MeSH
• metabolické nemoci * patofyziologie   metabolismus   etiologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH