BACKGROUND: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be the main source. To verify the involvement of inflammation in HOA pathogenesis, we evaluate serum inflammatory mediators and their association with HOA-related clinical features in patients. METHODS: 153 participants (50 non-erosive HOA patients, 54 erosive HOA patients, and 49 healthy control subjects) were included in this study. All patients underwent clinical examination, which included assessment of tender and swollen small hand joints, ultrasound (US) examination, and self-reported measures (e.g., AUSCAN or algofunctional indexes). Serum inflammatory mediators were quantified using human cytokine 27-plex immunoassay. We employed linear modelling, correlation analysis, and resampling statistics to evaluate the association of these mediators to HOA. RESULTS: We identified increased levels of nine inflammatory mediators (e.g., eotaxin, monocyte chemoattractant protein 1, interleukin-8, and tumour necrosis factor) in HOA patients compared to healthy controls. Increased mediators correlated with ultrasound findings as well as with clinically tender and swollen joint counts in patients with erosive HOA. However, none of the mediators distinguished between erosive and non-erosive HOA subtypes. CONCLUSION: Our findings support the hypothesis on the involvement of inflammation in HOA.

• Klíčová slova
• chemokines, cytokines, erosive disease, hand osteoarthritis,
• MeSH
• chemokin CCL11 krev   MeSH
• chemokin CCL2 krev   MeSH
• chemokiny krev   MeSH
• cytokiny krev   MeSH
• interleukin-8 krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• osteoartróza krev   patologie   MeSH
• progrese nemoci MeSH
• ruka patofyziologie   MeSH
• senioři MeSH
• TNF-alfa krev   MeSH
• zánět krev   patofyziologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• chemokin CCL11 MeSH
• chemokin CCL2 MeSH
• chemokiny MeSH
• cytokiny MeSH
• interleukin-8 MeSH
• TNF-alfa MeSH