All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.

• MeSH
• aklimatizace MeSH
• biologické modely MeSH
• fyziologická adaptace MeSH
• homeostáza * MeSH
• lidé MeSH
• tělesná teplota * MeSH
• teoretické modely MeSH
• termodynamika MeSH
• termoregulace * MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

While stress is a widely utilized concept, no direct methods facilitating its measurement are currently available. In our previous work we proposed stress entropic load (SEL) as a potential new marker of stress response in the human body. However, at that time no method for SEL measurement existed. In this pilot study we devised and then tested methodology for SEL measurement. Healthy male participants were monitored by indirect calorimetry and thermography while resting and subsequently while under prolonged mental effort. The acquired data was then used to calculate the temporal development of SEL for each participant. Our results show that SEL production increased significantly in participants subjected to prolonged mental effort. Furthermore, we observed that the calculated development of SEL over time may be used to accurately determine the time point at which participants started performing stressful tasks.

• MeSH
• biologické modely * MeSH
• dospělí MeSH
• entropie * MeSH
• lidé MeSH
• mladý dospělý MeSH
• nepřímá kalorimetrie MeSH
• neuropsychologické testy MeSH
• pilotní projekty MeSH
• psychický stres diagnóza   patofyziologie   MeSH
• termografie MeSH
• zdraví dobrovolníci pro lékařské studie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH