Herein, the recent advances in the development of resorbable polymeric-based biomaterials, their geometrical forms, resorption mechanisms, and their capabilities in various biomedical applications are critically reviewed. A comprehensive discussion of the engineering approaches for the fabrication of polymeric resorbable scaffolds for tissue engineering, drug delivery, surgical, cardiological, aesthetical, dental and cardiovascular applications, are also explained. Furthermore, to understand the internal structures of resorbable scaffolds, representative studies of their evaluation by medical imaging techniques, e.g., cardiac computer tomography, are succinctly highlighted. This approach provides crucial clinical insights which help to improve the materials' suitable and viable characteristics for them to meet the highly restrictive medical requirements. Finally, the aspects of the legal regulations and the associated challenges in translating research into desirable clinical and marketable materials of polymeric-based formulations, are presented.

• Klíčová slova
• clinical challenges, drug delivery, implants, medical imaging, polymer matrices, resorbable biomaterials, tissue engineering,
• MeSH
• biokompatibilní materiály chemie   MeSH
• lékové transportní systémy * metody   MeSH
• lidé MeSH
• polymery * chemie   MeSH
• tkáňové inženýrství * metody   MeSH
• tkáňové podpůrné struktury chemie   MeSH
• vstřebatelné implantáty MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• biokompatibilní materiály MeSH
• polymery * MeSH

Highly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress. In our study, highly porous CaP-based scaffolds were prepared via freeze-casting with longitudinal and oriented pores ranging from 10 to 20 μm and a relative porosity of ∼70%. The resulting scaffolds achieved a flexural strength of 10.6 ± 2.7 MPa, which, in conjunction with their favorable bioactivity, made them suitable for in vivo testing. The prepared scaffolds were subcutaneously implanted in rats for two distinct periods: 6 weeks and 6 months, respectively. The subsequent development of fibrous tissue and involvement of myofibroblasts, newly formed vessels, and macrophages were observed, with notable changes in spatial and temporal distributions within the implantation. The absence of calcification in the surrounding soft tissue, as a result of the narrow pore geometry, indicates the opportunity to tailor the scaffold behavior for soft tissue regeneration.

• Klíčová slova
• bioceramics, calcium phosphates, freeze-casting, in vivo, scaffolds, tissue engineering,
• MeSH
• biokompatibilní materiály chemie   farmakologie   MeSH
• fosforečnany vápenaté * chemie   farmakologie   MeSH
• krysa rodu Rattus MeSH
• poréznost MeSH
• potkani Sprague-Dawley MeSH
• testování materiálů MeSH
• tkáňové inženýrství MeSH
• tkáňové podpůrné struktury * chemie   MeSH
• zmrazování MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biokompatibilní materiály MeSH
• calcium phosphate MeSH Prohlížeč
• fosforečnany vápenaté * MeSH