• Klíčová slova
• antibody persistence, neutralizing titer, power-law models, tick-borne encephalitis, vaccination,
• MeSH
• klíšťová encefalitida * prevence a kontrola   MeSH
• lidé MeSH
• sekundární imunizace MeSH
• vakcinace MeSH
• vakcíny * MeSH
• viry klíšťové encefalitidy * imunologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• komentáře MeSH
• práce podpořená grantem MeSH
• Názvy látek
• vakcíny * MeSH

Tick-borne encephalitis (TBE) is an acute febrile illness with neurological manifestations that is prevalent in forested areas of moderate climate in Europe and Asia. TBE virus is transmitted by ticks and rarely by unpasteurized milk and dairy products. The disease burden is attributed mainly to resulting long-term disability, especially in individuals over 50 y of age. Currently, there is no causative treatment, but a very effective vaccination is available with a good safety profile. The vaccination requires 3 basic doses to be fully effective and regular boosters afterwards. An accelerated vaccination schedule enables a patient to reach reasonably protective titres within 3 to 4 weeks from the first injection. The risk of travel-related TBE is estimated to be less than the risk of acquiring typhoid fever while visiting highly endemic regions in South Asia, but more than the risk of acquiring Japanese encephalitis, meningococcal invasive disease, or rabies. The pre-travel risk assessment of acquiring TBE should consider known risk factors which include 1) the country and regions to be visited; 2) April to November season; 3) altitude less than 1500 m above the sea level; 4) duration of stay; 5) the extent of tick-exposure associated activities including leisure and professional outdoor activities within the endemic area; and 6) age and comorbidities of the traveler. A major challenge, however, is the very low awareness of the risk of contracting TBE in those who travel to industrialized European countries.

• Klíčová slova
• endemic country, flavivirus, tick-borne encephalitis, tick-borne encephalitis virus, travel medicine, vaccination,
• MeSH
• cestování * MeSH
• endemické nemoci * MeSH
• klíšťová encefalitida epidemiologie   prevence a kontrola   MeSH
• lidé MeSH
• virové vakcíny aplikace a dávkování   imunologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Geografické názvy
• Asie epidemiologie   MeSH
• Evropa epidemiologie   MeSH
• Názvy látek
• virové vakcíny MeSH