Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut⁻liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease.

• Keywords
• autoimmunity, celiac hepatitis, gut–liver axis, intestinal barrier, liver immunity, non-alcoholic fatty liver disease, tolerance,
• MeSH
• Autoimmunity * MeSH
• Hepatitis, Autoimmune diet therapy   epidemiology   immunology   microbiology   MeSH
• Autoantibodies immunology   MeSH
• Diet, Gluten-Free MeSH
• Celiac Disease diet therapy   epidemiology   immunology   microbiology   MeSH
• Dysbiosis MeSH
• Liver immunology   microbiology   MeSH
• Humans MeSH
• Non-alcoholic Fatty Liver Disease diet therapy   epidemiology   immunology   microbiology   MeSH
• Vitamin D Deficiency epidemiology   immunology   MeSH
• Permeability MeSH
• Prognosis MeSH
• Protein Glutamine gamma Glutamyltransferase 2 MeSH
• GTP-Binding Proteins immunology   MeSH
• Risk Factors MeSH
• Intestines immunology   MeSH
• Gastrointestinal Microbiome MeSH
• Intestinal Mucosa metabolism   MeSH
• Transglutaminases immunology   MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Autoantibodies MeSH
• Protein Glutamine gamma Glutamyltransferase 2 MeSH
• GTP-Binding Proteins MeSH
• Transglutaminases MeSH