Two structurally different copper(II) complexes of the compositions [{Cu(9dhx)(H2O)3}2(µ-SO4)2] (1) and [Cu(9dhx)2(H2O)2(NO3)2]·H2O (2), involving 9-deazahypoxanthine (9dhx; 6-oxo-9-deazapurine; 9-deazahypoxanthine), have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, electrospray ionisation (ESI) mass spectrometry, thermogravimetric (TG) and differential thermal (DTA) analyses, and cyclic voltammetry. The X-ray structures of complexes 1 and [Cu(9dhx)2(H2O)2(NO3)2] (2a) revealed the distorted octahedral geometry in the vicinity of the copper(II) atoms, with the NO5 and N2O4 donor set, respectively. In the dimeric compound 1, the {Cu(9dhx)(H2O)3}2 units are bridged by sulfate groups with the Cu···Cu separation being 5.3446(2) Å. In both structures the 9dhx ligands are coordinated through the N3 atoms of the pyrimidine moieties. The SOD-like activity of complexes 1 and 2 was evaluated in vitro showing moderate effect, with the IC50 values equal to 18.20, and 53.33 μM, respectively.

• Klíčová slova
• 6-oxo-9-deazapurine, 9-deazahypoxanthine, X-ray crystal structure, copper(II) complexes, in vitro SOD-like activity,
• MeSH
• biokompatibilní materiály chemie   metabolismus   MeSH
• elektrochemické techniky MeSH
• hmotnostní spektrometrie s elektrosprejovou ionizací MeSH
• hypoxanthiny chemie   MeSH
• komplexní sloučeniny chemie   metabolismus   MeSH
• krystalografie rentgenová MeSH
• měď chemie   MeSH
• molekulární konformace MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• superoxiddismutasa metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• 9-deazahypoxanthine MeSH Prohlížeč
• biokompatibilní materiály MeSH
• hypoxanthiny MeSH
• komplexní sloučeniny MeSH
• měď MeSH
• superoxiddismutasa MeSH