Type 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia. Studies have shown that if a patient's hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions. Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns. However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised. To address these questions, we examined 28 T1D women in reproductive age for the relationship between various metabolic, clinical, and immune parameters. Our study revealed several unexpected correlations which are indicative of a much more complex relationship between glucose and lipid factors (namely, glycosylated haemoglobin Hb1Ac, the presence of one but not multiple chronic diabetic complications, and atherogenic indexes) and proinflammatory cytokines (IL-1alpha and TNF-alpha). Regulatory T cell counts correlated with HbA1c, diabetic neuropathy, lipid spectra parameters, and IL-6 levels. Total T-helper cell count was interconnected with BMI and glycaemia variability correlated with lipid spectra parameters, insulin dose, and vitamin D levels. These and other correlations revealed in this study provide broader insight into the association of various metabolic abnormalities with immune parameters that may impact T1D mothers or their developing child.

• MeSH
• cytokiny imunologie   MeSH
• diabetes mellitus 1. typu komplikace   farmakoterapie   imunologie   metabolismus   MeSH
• diabetické neuropatie etiologie   imunologie   MeSH
• dospělí MeSH
• glykovaný hemoglobin metabolismus   MeSH
• HDL-cholesterol metabolismus   MeSH
• hypoglykemika aplikace a dávkování   MeSH
• interleukin-1alfa imunologie   MeSH
• interleukin-6 imunologie   MeSH
• inzulin aplikace a dávkování   MeSH
• LDL-cholesterol metabolismus   MeSH
• lidé MeSH
• mladý dospělý MeSH
• počet lymfocytů MeSH
• produkty pokročilé glykace metabolismus   MeSH
• regulační T-lymfocyty imunologie   MeSH
• T-lymfocyty pomocné-indukující imunologie   MeSH
• TNF-alfa imunologie   MeSH
• triglyceridy metabolismus   MeSH
• vitamin D metabolismus   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cytokiny MeSH
• glykovaný hemoglobin MeSH
• HDL-cholesterol MeSH
• hemoglobin A1c protein, human MeSH Prohlížeč
• hypoglykemika MeSH
• IL1A protein, human MeSH Prohlížeč
• IL6 protein, human MeSH Prohlížeč
• interleukin-1alfa MeSH
• interleukin-6 MeSH
• inzulin MeSH
• LDL-cholesterol MeSH
• produkty pokročilé glykace MeSH
• TNF protein, human MeSH Prohlížeč
• TNF-alfa MeSH
• triglyceridy MeSH
• vitamin D MeSH