Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) that transgenically express human C-reactive protein (SHR-CRP rats). We treated 15-month-old male transgenic SHR-CRP rats and nontransgenic SHR with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP and SHR rats were fed a standard diet without salsalate. In the SHR-CRP transgenic strain, salsalate treatment decreased circulating concentrations of the inflammatory markers TNF-α and MCP-1, reduced oxidative stress in the liver and kidney, increased sensitivity of skeletal muscles to insulin action and improved tolerance to glucose. In SHR controls with no CRP-induced inflammation, salsalate treatment reduced body weight, decreased concentrations of serum free fatty acids and total and HDL cholesterol and increased palmitate oxidation and incorporation in brown adipose tissue. Salsalate regulated inflammation by affecting the expression of genes from MAPK signalling and NOD-like receptor signalling pathways and lipid metabolism by affecting hepatic expression of genes that favour lipid oxidation from PPAR-α signalling pathways. These findings suggest that salsalate has metabolic effects beyond suppressing inflammation.

• MeSH
• C-reaktivní protein biosyntéza   genetika   MeSH
• geneticky modifikovaná zvířata genetika   MeSH
• hnědá tuková tkáň metabolismus   MeSH
• hypertenze farmakoterapie   genetika   patologie   MeSH
• inzulinová rezistence genetika   MeSH
• játra metabolismus   MeSH
• krysa rodu Rattus MeSH
• kyseliny mastné neesterifikované metabolismus   MeSH
• lidé MeSH
• metabolický syndrom farmakoterapie   genetika   patologie   MeSH
• metabolismus lipidů účinky léků   MeSH
• NLR proteiny biosyntéza   MeSH
• oxidační stres účinky léků   MeSH
• PPAR alfa biosyntéza   MeSH
• salicylany aplikace a dávkování   MeSH
• TNF-alfa biosyntéza   MeSH
• zánět farmakoterapie   genetika   patologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• C-reaktivní protein MeSH
• kyseliny mastné neesterifikované MeSH
• NLR proteiny MeSH
• PPAR alfa MeSH
• salicylany MeSH
• salicylsalicylic acid MeSH Prohlížeč
• TNF-alfa MeSH