Immunobiological activity of the polybacterial lysate Olimunostim (P. acnes, K. pneumoniae, S. aureus) was examined by investigating its effects on murine lymphocytes. When added to in vitro lymphocyte cultures, Olimunostim induced interleukin-2 (IL-2) biological activity (in a 2-d culture) and subsequently potentiated lymphocyte proliferation (on day 3); the latter effect was dependent on the presence of adherent cells. In vivo, significant enhancement of lymphocyte reactivity to T-mitogens and increase of CD4+ helper-inducer T lymphocytes were observed 3 d after a subcutaneous application of Olimunostim to mice with cellular immune deficiency. These results confirm the modulatory properties of Olimunostim towards lymphocytes both in vitro and in vivo, which may form a basis for its clinical application.

• MeSH
• adjuvancia imunologická metabolismus   farmakologie   MeSH
• aktivace lymfocytů MeSH
• buněčná imunita * MeSH
• interleukin-2 biosyntéza   MeSH
• Klebsiella pneumoniae metabolismus   MeSH
• konkanavalin A farmakologie   MeSH
• lymfocyty imunologie   MeSH
• myši inbrední BALB C MeSH
• myši MeSH
• Propionibacterium acnes metabolismus   MeSH
• Staphylococcus aureus metabolismus   MeSH
• syndromy imunologické nedostatečnosti imunologie   terapie   MeSH
• T-lymfocyty imunologie   MeSH
• techniky in vitro MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adjuvancia imunologická MeSH
• interleukin-2 MeSH
• konkanavalin A MeSH