Immunobiological activity of the polybacterial lysate Olimunostim (P. acnes, K. pneumoniae, S. aureus) was examined by investigating its effects on murine lymphocytes. When added to in vitro lymphocyte cultures, Olimunostim induced interleukin-2 (IL-2) biological activity (in a 2-d culture) and subsequently potentiated lymphocyte proliferation (on day 3); the latter effect was dependent on the presence of adherent cells. In vivo, significant enhancement of lymphocyte reactivity to T-mitogens and increase of CD4+ helper-inducer T lymphocytes were observed 3 d after a subcutaneous application of Olimunostim to mice with cellular immune deficiency. These results confirm the modulatory properties of Olimunostim towards lymphocytes both in vitro and in vivo, which may form a basis for its clinical application.

• MeSH
• Adjuvants, Immunologic metabolism   pharmacology   MeSH
• Lymphocyte Activation MeSH
• Immunity, Cellular * MeSH
• Interleukin-2 biosynthesis   MeSH
• Klebsiella pneumoniae metabolism   MeSH
• Concanavalin A pharmacology   MeSH
• Lymphocytes immunology   MeSH
• Mice, Inbred BALB C MeSH
• Mice MeSH
• Propionibacterium acnes metabolism   MeSH
• Staphylococcus aureus metabolism   MeSH
• Immunologic Deficiency Syndromes immunology   therapy   MeSH
• T-Lymphocytes immunology   MeSH
• In Vitro Techniques MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Adjuvants, Immunologic MeSH
• Interleukin-2 MeSH
• Concanavalin A MeSH