Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological processes such as the metabolism of drugs/xenobiotics and endogenous compounds including lipids and carbohydrates, and inflammation. Algae, sponges, sea squirts, and other marine organisms are some of the species from which structurally new molecules have been isolated that have been subsequently identified in recent decades as ligands for PXR. The therapeutic potential of these natural compounds is promising in different areas and has recently resulted in the registration of trabectedin by the FDA as a novel antineoplastic drug. Apart from being potentially novel drugs, these compounds can also serve as models for the development of new molecules with improved activity. The aim of this review is to succinctly summarize the currently known natural molecules isolated from marine organisms with a proven ability to interact with PXR.

• Keywords
• CYP450, PXR, cancer, gene regulation, inflammation, marine origin, natural compound,
• MeSH
• Biological Products chemistry   isolation & purification   pharmacology   MeSH
• Humans MeSH
• Ligands MeSH
• Molecular Structure MeSH
• Porifera chemistry   MeSH
• Pregnane X Receptor metabolism   MeSH
• Gene Expression Regulation drug effects   MeSH
• Urochordata chemistry   MeSH
• Aquatic Organisms chemistry   MeSH
• Drug Development * MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Biological Products MeSH
• Ligands MeSH
• Pregnane X Receptor MeSH