Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.

• Keywords
• SERM, isoflavone, phytoestrogen, regeneration, repair, scar, skin wound,
• MeSH
• Phytoestrogens pharmacology   MeSH
• Genistein pharmacology   MeSH
• Wound Healing drug effects   MeSH
• Humans MeSH
• Regenerative Medicine trends   MeSH
• Selective Estrogen Receptor Modulators pharmacology   MeSH
• Signal Transduction MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Phytoestrogens MeSH
• Genistein MeSH
• Selective Estrogen Receptor Modulators MeSH