Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.

Department of Biomedical Research East Slovak Institute of Cardiovascular Diseases Inc 040 11 Košice Slovakia

Department of Pharmacognosy and Botany Faculty of Pharmacy Comenius University 832 32 Bratislava Slovakia

Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University 040 11 Košice Slovakia

Laboratory of Cell Interactions Faculty of Medicine Pavol Jozef Šafárik University 040 11 Košice Slovakia

Prague Burn Center 3rd Faculty of Medicine Charles University 100 34 Prague Czech Republic

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Agrimonia eupatoria L. Aqueous Extract Improves Skin Wound Healing: An In Vitro Study in Fibroblasts and Keratinocytes and In Vivo Study in Rats