Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.

BIOCEV 252 50 Vestec Czech Republic

Center of Clinical and Preclinical Research MediPark Pavol Jozef Šafárik University 040 11 Košice Slovakia

Department of Biomedical Research East Slovak Institute of Cardiovascular Diseases Inc 040 11 Košice Slovakia

Department of Otorhinolaryngology Head and Neck Surgery 1st Faculty of Medicine Charles University and University Hospital Motol 150 06 Prague Czech Republic

Department of Pathology Louise Pasteur University Hospital 041 90 Košice Slovakia

Department of Pharmacology Faculty of Medicine Pavol Jozef Šafárik University 040 11 Košice Slovakia

Institute of Anatomy 1st Faculty of Medicine Charles University 128 00 Prague Czech Republic

Prague Burn Centre 3rd Faculty of Medicine Charles University and University Hospital Královské Vinohrady 100 34 Prague Czech Republic

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