The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of quinolones (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin), aminoglycosides (amikacin, gentamicin, netilmicin, streptomycin, tobramycin), beta-lactams (aztreonam, ceftazidime, imipenem, ticarcilin) and macrolides (erythromycin, roxitromycin) on the excretion of alginate by a P. aeruginosa strain were studied. Both beta-lactam and macrolide antibiotics were found ineffective at the concentrations tested, except erythromycin and imipenem at 1/4 MIC. Aminoglycosides at a concentration of 1/4 MIC reduced most effectively the excretion of alginate. Quinolones were also effective at this sub-MIC; 1/16 MIC was ineffective with all antibiotics or stimulated the production of alginate.

• MeSH
• Alginates metabolism   MeSH
• Aminoglycosides MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Quinolones pharmacology   MeSH
• Lactams MeSH
• Macrolides MeSH
• Microbial Sensitivity Tests MeSH
• Pseudomonas aeruginosa drug effects   metabolism   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Alginates MeSH
• Aminoglycosides MeSH
• Anti-Bacterial Agents MeSH
• Quinolones MeSH
• Lactams MeSH
• Macrolides MeSH