Most cited article - PubMed ID 3139304
Novsie poznatky o toxických produktoch Pseudomonas aeruginosa
[New findings on the toxic products of Pseudomonas aeruginosa]
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of quinolones (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin), aminoglycosides (amikacin, gentamicin, netilmicin, streptomycin, tobramycin), beta-lactams (aztreonam, ceftazidime, imipenem, ticarcilin) and macrolides (erythromycin, roxitromycin) on the excretion of alginate by a P. aeruginosa strain were studied. Both beta-lactam and macrolide antibiotics were found ineffective at the concentrations tested, except erythromycin and imipenem at 1/4 MIC. Aminoglycosides at a concentration of 1/4 MIC reduced most effectively the excretion of alginate. Quinolones were also effective at this sub-MIC; 1/16 MIC was ineffective with all antibiotics or stimulated the production of alginate.
- MeSH
- Alginates metabolism MeSH
- Aminoglycosides MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Quinolones pharmacology MeSH
- Lactams MeSH
- Macrolides MeSH
- Microbial Sensitivity Tests MeSH
- Pseudomonas aeruginosa drug effects metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alginates MeSH
- Aminoglycosides MeSH
- Anti-Bacterial Agents MeSH
- Quinolones MeSH
- Lactams MeSH
- Macrolides MeSH