The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of quinolones (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin), aminoglycosides (amikacin, gentamicin, netilmicin, streptomycin, tobramycin), beta-lactams (aztreonam, ceftazidime, imipenem, ticarcilin) and macrolides (erythromycin, roxitromycin) on the excretion of alginate by a P. aeruginosa strain were studied. Both beta-lactam and macrolide antibiotics were found ineffective at the concentrations tested, except erythromycin and imipenem at 1/4 MIC. Aminoglycosides at a concentration of 1/4 MIC reduced most effectively the excretion of alginate. Quinolones were also effective at this sub-MIC; 1/16 MIC was ineffective with all antibiotics or stimulated the production of alginate.

• MeSH
• algináty metabolismus   MeSH
• aminoglykosidy MeSH
• antibakteriální látky farmakologie   MeSH
• chinolony farmakologie   MeSH
• laktamy MeSH
• makrolidy MeSH
• mikrobiální testy citlivosti MeSH
• Pseudomonas aeruginosa účinky léků   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• algináty MeSH
• aminoglykosidy MeSH
• antibakteriální látky MeSH
• chinolony MeSH
• laktamy MeSH
• makrolidy MeSH