Methamphetamine (MA), as massively abused psychoactive stimulant, has been associated with many neurological diseases. It has various potent and neurotoxic properties. There are many mechanisms of action that contribute to its neurotoxic and degenerative effects, including excessive neurotransmitter (NEU) release, blockage of NEU uptake transporters, degeneration of NEU receptors, process of oxidative stress etc. MA intoxication is caused by blood-brain barrier disruption resulted from MA-induced oxidation stress. In our laboratory we constantly work on animal research of MA. Our current interest is to investigate processes of MA-induced alteration in neurotransmission, especially during development of laboratory rat. This review will describe current understanding in role of NEUs, which are affected by MA-induced neurotoxicity caused by altering the action of NEUs in the central nervous system (CNS). It also briefly brings information about NEUs development in critical periods of development.

• MeSH
• centrální nervový systém účinky léků   růst a vývoj   metabolismus   MeSH
• chování zvířat účinky léků   MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• methamfetamin toxicita   MeSH
• nervový přenos účinky léků   MeSH
• neurogeneze účinky léků   MeSH
• neurotoxické syndromy etiologie   metabolismus   patologie   MeSH
• neurotransmiterové látky toxicita   MeSH
• stimulanty centrálního nervového systému toxicita   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• methamfetamin MeSH
• neurotransmiterové látky MeSH
• stimulanty centrálního nervového systému MeSH