Nejvíce citovaný článek - PubMed ID 31597012
Low incidence of atrial septal defects in nonmammalian vertebrates
A well-developed heart is essential for embryonic survival. There are constant interactions between cardiac tissue motion and blood flow, which determine the heart shape itself. Hemodynamic forces are a powerful stimulus for cardiac growth and differentiation. Therefore, it is particularly interesting to investigate how the blood flows through the heart and how hemodynamics is linked to a particular species and its development, including human. The appropriate patterns and magnitude of hemodynamic stresses are necessary for the proper formation of cardiac structures, and hemodynamic perturbations have been found to cause malformations via identifiable mechanobiological molecular pathways. There are significant differences in cardiac hemodynamics among vertebrate species, which go hand in hand with the presence of specific anatomical structures. However, strong similarities during development suggest a common pattern for cardiac hemodynamics in human adults. In the human fetal heart, hemodynamic abnormalities during gestation are known to progress to congenital heart malformations by birth. In this chapter, we discuss the current state of the knowledge of the prenatal cardiac hemodynamics, as discovered through small and large animal models, as well as from clinical investigations, with parallels gathered from the poikilotherm vertebrates that emulate some hemodynamically significant human congenital heart diseases.
- Klíčová slova
- Axolotl, Chick embryo, DORV, Developing myocardium, ET1, Embryogenesis, Endothelin 1, Fetal heart, Guinea pig, HLHS, Hemodynamics, Hyperplasia, Hypertrophy, Hypoplastic left heart syndrome, KLF2, Krüppel-like factor 2, Lamb, Mouse, NOS3, Nitric oxide synthase 3, Pressure overload, Rat, Reptile, VSD, Volume overload, Zebrafish,
- MeSH
- hemodynamika * fyziologie MeSH
- lidé MeSH
- srdce * růst a vývoj fyziologie MeSH
- vrozené srdeční vady patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cor triatriatum is a very rare cardiac malformation characterized by the presence of an abnormal interatrial membrane separating either the left or right atrial chamber into two compartments. It can be associated with other cardiac defects and is often symptomatic in childhood. The signs depend on the size and position of the interatrial membrane and other associated malformations. Here we report a case of right-sided cor triatriatum associated with an ostium primum-type interatrial septum defect and left-sided opening of the coronary sinus in a fetus. The cause of intrauterine death was asphyxia due to total placental abruption.
