BACKGROUND: Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. METHODS: The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. RESULTS: Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. CONCLUSIONS: Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.

• Keywords
• 25-hydroxyvitamin D, Adipocyte fatty acid binding protein, Adiponectin, Inflammatory bowel disease, Nesfatin-1, Resistin, Retinol-binding protein 4,
• MeSH
• Adipokines * blood   MeSH
• Adiponectin blood   deficiency   MeSH
• Biomarkers blood   MeSH
• Child MeSH
• DNA-Binding Proteins blood   MeSH
• Inflammatory Bowel Diseases blood   complications   MeSH
• Humans MeSH
• Adolescent MeSH
• Vitamin D Deficiency * complications   blood   MeSH
• Nucleobindins blood   MeSH
• Retinol-Binding Proteins, Plasma metabolism   analysis   MeSH
• Fatty Acid-Binding Proteins blood   MeSH
• Calcium-Binding Proteins blood   MeSH
• Resistin blood   MeSH
• Case-Control Studies MeSH
• Vitamin D * blood   analogs & derivatives   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• 25-hydroxyvitamin D MeSH Browser
• Adipokines * MeSH
• Adiponectin MeSH
• Biomarkers MeSH
• DNA-Binding Proteins MeSH
• FABP4 protein, human MeSH Browser
• NUCB2 protein, human MeSH Browser
• Nucleobindins MeSH
• Retinol-Binding Proteins, Plasma MeSH
• Fatty Acid-Binding Proteins MeSH
• Calcium-Binding Proteins MeSH
• RBP4 protein, human MeSH Browser
• Resistin MeSH
• Vitamin D * MeSH

Wnt1 inducible protein-1 signaling pathway (WISP-1) is a relatively new adipokine involved in many cellular processes, including epithelial mucosa healing. The aim of the study was to compare circulating levels of WISP-1 and other selected adipokines [adiponectin, resistin and retinol-binding protein 4 (RBP-4)] in children with inflammatory bowel disease (IBD) with healthy controls and to investigate possible differences between Crohn's disease patients. (CD) or ulcerative colitis (UC). The study was performed as a case-control study. In addition to adipokines, anthropometric, lipid parameters, markers of inflammation or disease activity were evaluated in all participants. Compared to healthy controls (n=20), significantly lower levels of adiponectin and higher levels of resistin and WISP-1 were found in patients with IBD (n=58). Elevation of WISP-1 was detected only in the CD group (n=31). There were no differences in RBP-4 levels between the groups. Adiponectin, WISP-1 and RBP-4 were independently associated with body mass index only, resistin levels were associated with C-reactive protein levels and leukocyte counts. Adverse adipokines production reflects presence of dysfunctional fat tissue in IBD patients. Higher levels of WISP-1 in CD compared to patients with UC may indicate a specific role for mesenteric adipose tissue in WISP-1 production.

• MeSH
• Adipokines MeSH
• Adiponectin MeSH
• Child MeSH
• Inflammatory Bowel Diseases * MeSH
• Humans MeSH
• CCN Intercellular Signaling Proteins blood   MeSH
• Proto-Oncogene Proteins blood   MeSH
• Resistin MeSH
• Signal Transduction MeSH
• Case-Control Studies MeSH
• Colitis, Ulcerative * MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Adipokines MeSH
• Adiponectin MeSH
• CCN4 protein, human MeSH Browser
• CCN Intercellular Signaling Proteins MeSH
• Proto-Oncogene Proteins MeSH
• Resistin MeSH