The passage of 6 model drugs; acetylsalicylic acid, chloramphenicol, ethimizol, carbisocaine, heptacaine, and diazepam, through the blood-brain barrier, was determined in unirradiated control rats and in animals 1, 3, and 7 days after irradiation of the head only with a dose of 25 Gy from a 60Co source. The brain uptake index (BUI), which compares the uptake of the test substance with that of 3H2O 5 s after their injection into the common carotid artery, was significantly increased in comparison with unirradiated controls 7 days after irradiation, for all substances tested except for ethimizol. For acetylsalicylic acid and chloramphenicol it was also significantly increased in the other time intervals. The less lipophilic substances showed a greater relative increase of BUI than the more lipophilic ones.

• MeSH
• Aspirin farmakokinetika   MeSH
• chloramfenikol farmakokinetika   MeSH
• diazepam farmakokinetika   MeSH
• etimizol farmakokinetika   MeSH
• hematoencefalická bariéra účinky záření   MeSH
• inbrední kmeny potkanů MeSH
• karbamáty farmakokinetika   MeSH
• kraniální ozáření * MeSH
• krysa rodu Rattus MeSH
• mozek metabolismus   MeSH
• piperidiny farmakokinetika   MeSH
• radioizotopy kobaltu MeSH
• regresní analýza MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• Aspirin MeSH
• carbizocaine MeSH Prohlížeč
• chloramfenikol MeSH
• diazepam MeSH
• etimizol MeSH
• heptacaine MeSH Prohlížeč
• karbamáty MeSH
• piperidiny MeSH
• radioizotopy kobaltu MeSH