Irradiation of the head by 60Co opens the blood-brain barrier for drugs in rats
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
2226715
DOI
10.1007/bf01940660
Knihovny.cz E-zdroje
- MeSH
- Aspirin farmakokinetika MeSH
- chloramfenikol farmakokinetika MeSH
- diazepam farmakokinetika MeSH
- etimizol farmakokinetika MeSH
- hematoencefalická bariéra účinky záření MeSH
- inbrední kmeny potkanů MeSH
- karbamáty farmakokinetika MeSH
- kraniální ozáření * MeSH
- krysa rodu Rattus MeSH
- mozek metabolismus MeSH
- piperidiny farmakokinetika MeSH
- radioizotopy kobaltu MeSH
- regresní analýza MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- Aspirin MeSH
- carbizocaine MeSH Prohlížeč
- chloramfenikol MeSH
- diazepam MeSH
- etimizol MeSH
- heptacaine MeSH Prohlížeč
- karbamáty MeSH
- piperidiny MeSH
- radioizotopy kobaltu MeSH
The passage of 6 model drugs; acetylsalicylic acid, chloramphenicol, ethimizol, carbisocaine, heptacaine, and diazepam, through the blood-brain barrier, was determined in unirradiated control rats and in animals 1, 3, and 7 days after irradiation of the head only with a dose of 25 Gy from a 60Co source. The brain uptake index (BUI), which compares the uptake of the test substance with that of 3H2O 5 s after their injection into the common carotid artery, was significantly increased in comparison with unirradiated controls 7 days after irradiation, for all substances tested except for ethimizol. For acetylsalicylic acid and chloramphenicol it was also significantly increased in the other time intervals. The less lipophilic substances showed a greater relative increase of BUI than the more lipophilic ones.
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