Multifunctional polymers are interesting substances for the formulation of drug molecules that cannot be administered in their pure form due to their pharmacokinetic profiles or side effects. Polymer-drug formulations can enhance pharmacological properties or create tissue specificity by encapsulating the drug into nanocontainers, or stabilizing nanoparticles for drug transport. We present the synthesis of multifunctional poly(2-ethyl-2-oxazoline-co-2-glyco-2-oxazoline)s containing two reactive end groups, and an additional hydrophobic anchor at one end of the molecule. These polymers were successfully used to stabilize (solid) lipid nanoparticles ((S)LNP) consisting of tetradecan-1-ol and cholesterol with their hydrophobic anchor. While the pure polymers interacted with GLUT1-expressing cell lines mainly based on their physicochemical properties, especially via interactions of the hydrophobic anchor with membranous compartments of the cells, LNP-cell interactions hinted toward an influence of the glucosylation on particle-cell interactions. The presented LNP are therefore promising systems for the delivery of drugs into GLUT1-expressing cell lines.

• MeSH
• Hydrophobic and Hydrophilic Interactions MeSH
• Humans MeSH
• Lipids * chemistry   MeSH
• Nanoparticles * chemistry   MeSH
• Drug Carriers chemistry   MeSH
• Oxazoles * chemistry   MeSH
• Polymers * chemistry   MeSH
• Glucose Transporter Type 1 metabolism   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Lipids * MeSH
• Drug Carriers MeSH
• Oxazoles * MeSH
• poly(2-oxazoline) MeSH Browser
• Polymers * MeSH
• Glucose Transporter Type 1 MeSH
• SLC2A1 protein, human MeSH Browser