The rate of hexose transport was approximately 60% lower for both the high- and the low-affinity components of hexose uptake when a glucose-6-phosphate isomerase mutant of Saccharomyces cerevisiae was preincubated with glucose, as compared with preincubation with water. Similarly the Jmax value of the high-affinity system of the mutant was 25-35% of the corresponding Jmax value for normal cells incubated with glucose. Accumulation of glucose 6-phosphate or of some other metabolite, such as fructose 6-phosphate or trehalose, may be responsible for this striking inhibition.

• MeSH
• aktivní transport účinky léků   MeSH
• glukosa-6-fosfátisomerasa genetika   metabolismus   MeSH
• glukosa farmakologie   MeSH
• hexosy farmakokinetika   MeSH
• kinetika MeSH
• mutace MeSH
• Saccharomyces cerevisiae genetika   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• glukosa-6-fosfátisomerasa MeSH
• glukosa MeSH
• hexosy MeSH