Numerous antibodies with a known mechanism of action are utilized as possible means for studying morphogenesis and differentiation. Inhibitors of biosynthesis of nucleic acids and proteins, compounds intervening with the synthesis and/or function of cell walls and membranes or compounds influencing the energy metabolism are particularly useful. The use of antibiotics for studies of the life cycle of viruses, bacteria, fungi, myxomycetes, protozoa and algae is analyzed in the present communication. Certain aspects of morphogenesis and functions of mitochondria and plastids were clarified with the aid of antibiotics. Relationships between production of antibiotics and differentiation of their producers are discussed in the final part of the paper.

• MeSH
• antibakteriální látky biosyntéza   farmakologie   MeSH
• Bacteria růst a vývoj   MeSH
• chloroplasty fyziologie   MeSH
• Eukaryota růst a vývoj   MeSH
• houby růst a vývoj   MeSH
• mitochondrie fyziologie   MeSH
• morfogeneze MeSH
• organoidy fyziologie   MeSH
• spory hub fyziologie   MeSH
• viry růst a vývoj   MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• antibakteriální látky MeSH

The effect of ten derivatives of carbonylcyanide phenylhydrazone on growth of bacteria, yeast and different species of filamentous fungi was investigated. In yeast and mitochondria isolated from rat liver the effect of these derivatives on the respiratory activity was also followed. The relative efficiency of the individual derivatives of carbonylcyanide phenylhydrazone was determined on the basis of the results obtained. It was shown that derivatives, in which the substituent on the benzene ring causes simultaneously an increase of acidity and lipophilicity of the derivative as compared with the non-substituted carbonylcyanide phenylhydrazone (4-trifluoromethoxy-, 3-chloro-, 4-chloro and 3,4-dichloro-derivatives) were most effective.

• MeSH
• Bacillus cereus růst a vývoj   MeSH
• houby růst a vývoj   MeSH
• jaterní mitochondrie metabolismus   MeSH
• karbonylkyanid-m-chlorfenylhydrazon analogy a deriváty   farmakologie   MeSH
• karbonylkyanid-p-trifluormethoxyfenylhydrazon farmakologie   MeSH
• krysa rodu Rattus MeSH
• nitrily farmakologie   MeSH
• Saccharomyces cerevisiae růst a vývoj   metabolismus   MeSH
• spotřeba kyslíku MeSH
• vztahy mezi strukturou a aktivitou MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• karbonylkyanid-m-chlorfenylhydrazon MeSH
• karbonylkyanid-p-trifluormethoxyfenylhydrazon MeSH
• nitrily MeSH