Antibacterial, antifungal and antiprotozoal effects of nine mono- and bishydrazones of glycolaldehyde, glyoxal, methoxyacetaldehyde and glutaraldehyde were studied using eight model organisms. It was found that bishydrazones are much more efficient antimicrobial agents than monohydrazones in the case of all model microorganisms.

• MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Biotransformation MeSH
• Candida albicans drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines biosynthesis   metabolism   MeSH
• Hydrazones metabolism   pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Saccharomyces cerevisiae drug effects   MeSH
• Staphylococcus aureus drug effects   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Phenylhydrazines MeSH
• Hydrazones MeSH

Antiprotozoal effects of hydrazones derived from compounds with 1 to 4 carbon atoms were studied on the model organism Trichomonas vaginalis isolated from a female patient with acute urogenital trichomoniasis.

• MeSH
• Antiprotozoal Agents pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Metronidazole pharmacology   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Antiprotozoal Agents MeSH
• Hydrazones MeSH
• Metronidazole MeSH

The antimicrobial effect of 14 sugar osazones and anhydro sugars was studied with model strains of Micrococcus luteus, Bacillus licheniformis, Escherichia coli and strains Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical material. The relationship between the structure of these compounds, their solubility in water and 1-octanol and antimicrobial effect was investigated.

• MeSH
• Bacillus drug effects   MeSH
• Bacteria drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Hexoses pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Solubility MeSH
• Staphylococcus aureus drug effects   MeSH
• Structure-Activity Relationship MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Hexoses MeSH
• Hydrazones MeSH