Nitric oxide is a highly reactive gas that is produced by many tissues and exerts a series of physiological and pathophysiological effects. We studied the changes of the serum testosterone, thyroxine and thyrotropin levels, thyroid and anterior pituitary weights and thyroid cGMP concentrations in male Wistar strain rats treated with estradiol benzoate (EB) (1 mg/kg, im twice a week) and nonselective NO-synthase inhibitor L-NAME (N-omega-nitro-L-arginine methyl ester) alone and with combination of these substances. We have found that L-NAME in a dose 100 mg/kg/day but not in a dose 50 mg/kg/day increased the serum thyroxine and testosterone levels and in the case of testosterone in a higher dose partially blocked its drop when administered simultaneously with EB. The serum thyrotropin levels significantly fell after L-NAME and EB treatment. The cGMP thyroid levels changed only slightly in groups treated EB and L-NAME alone and were significantly decreased in group treated with combination of these substances. The nitric oxide thus seems to be an important modulator of thyroid and testicular function. The cGMP activation cascade is not probably involved in the nitric oxide induced changes of thyroid function.

• MeSH
• adenohypofýza účinky léků   metabolismus   MeSH
• estradiol farmakologie   MeSH
• guanosinmonofosfát cyklický metabolismus   MeSH
• inhibitory enzymů farmakologie   MeSH
• krysa rodu Rattus MeSH
• NG-nitroargininmethylester aplikace a dávkování   farmakologie   MeSH
• potkani Wistar MeSH
• štítná žláza účinky léků   fyziologie   MeSH
• synthasa oxidu dusnatého antagonisté a inhibitory   MeSH
• testosteron krev   MeSH
• thyreotropin krev   MeSH
• thyroxin krev   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• estradiol MeSH
• guanosinmonofosfát cyklický MeSH
• inhibitory enzymů MeSH
• NG-nitroargininmethylester MeSH
• synthasa oxidu dusnatého MeSH
• testosteron MeSH
• thyreotropin MeSH
• thyroxin MeSH